2-[4-(2-Amino-2-hydroxyethyl)-7,10-bis(2-amino-2-oxoethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[4-(2-Amino-2-hydroxyethyl)-7,10-bis(2-amino-2-oxoethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetamide
• 英文别名: 2-[4-(2-amino-2-hydroxyethyl)-7,10-bis(2-amino-2-oxoethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetamide
• 化学式: C₁₆H₃₄N₈O₄
• 分子量: 402.49
• InChiKey: CTWPGQCBCDAFIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.5
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  189
• 氢给体数：
  5
• 氢受体数：
  9

文献信息

• ANTIBODIES FOR CHELATED RADIONUCLIDES
  申请人：Hoffmann-La Roche Inc.

  公开号：US20220389116A1

  公开（公告）日：2022-12-08

  The present application relates to antibodies which bind specifically to chelated radionuclides, including bispecific antibodies. It further relates to the use of such bispecific antibodies in applications such as radioimmunoimaging and radioimmunotherapy. It additionally relates to clearing agents and compositions useful in such methods. The chelated radionuclides may be a DOTAM-lead (Pb) chelate.