Methyl 5-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3-methylpenta-2,4-dienoate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: Methyl 5-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3-methylpenta-2,4-dienoate
• 英文别名: methyl 5-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3-methylpenta-2,4-dienoate
• 化学式: C₂₄H₂₄FNO₂
• 分子量: 377.4
• InChiKey: QJPJQHOPURSSCK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  31.2
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Process for the preparation of indole derivatives and intermediates of the process
  申请人：——

  公开号：US20030166946A1

  公开（公告）日：2003-09-04

  A process for the preparation of compounds of formula (1), wherein R 1 is C 1 -C 6 alkyl and X is hydrogen, a hydrocarbon radical or a cation, wherein a compound of formula (2), wherein R 1 is as defined above and R 2 is hydrogen or a hydrocarbon radical, is reduced, the resulting compound of formula (3) is reacted with a compound that introduces the radical of formula —CH 2 —COOR 3 , wherein R 3 has the meanings given above for R 2 , and the resulting compound of formula (4) is reduced and optionally hydrolysed.

  一种制备化合物的方法，该化合物的化学式为（1），其中R1是C1-C6烷基，X是氢、烃基或阳离子，其中化合物的化学式为（2），其中R1如上定义，R2是氢或烃基，被还原，得到的化合物的化学式为（3），与引入化学式—CH2—COOR3的基团的化合物反应，其中R3具有上述所述的R2的含义，得到的化合物的化学式为（4），被还原并可选择性地水解。
• PROCESS FOR THE PREPARATION OF INDOLE DERIVATIVES AND INTERMEDIATES OF THE PROCESS
  申请人：Ciba Specialty Chemicals Holding Inc.

  公开号：EP1284964A1

  公开（公告）日：2003-02-26
• US6743926B2
  申请人：——

  公开号：US6743926B2

  公开（公告）日：2004-06-01
• [EN] PROCESS FOR THE PREPARATION OF INDOLE DERIVATIVES AND INTERMEDIATES OF THE PROCESS<br/>[FR] PROCESSUS DE PREPARATION DE DERIVES INDOLE ET D'INTERMEDIAIRES DE CE PROCESSUS
  申请人：CIBA SC HOLDING AG

  公开号：WO2001092223A1

  公开（公告）日：2001-12-06

  A process for the preparation of compounds of formula (1), wherein R1 is C1-C6alkyl and X is hydrogen, a hydrocarbon radical or a cation, wherein a compound of formula (2), wherein R1 is as defined above and R2 is hydrogen or a hydrocarbon radical, is reduced, the resulting compound of formula (3) is reacted with a compound that introduces the radical of formula -CH2-COOR3, wherein R3 has the meanings given above for R2, and the resulting compound of formula (4) is reduced and optionally hydrolysed.