12-hydroxyoctadecanal | 109555-62-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 12-hydroxyoctadecanal
• CAS: 109555-62-6
• 化学式: C₁₈H₃₆O₂
• 分子量: 284.483
• InChiKey: RRWVBDBMLULUGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  20
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  12-hydroxyoctadecanal 在 barium copper chromite 作用下， 生成 1,12-十八烷二醇
  参考文献：
  名称：

  Process for producing alcohols from hydroxy carboxylic compounds

  摘要：

  公开号：

  US02094611A1
• 作为产物：
  描述：

  1,12-十八烷二醇 在 sodium hypochlorite 、 2,2,6,6-四甲基哌啶氧化物 、 四丁基溴化铵 、 碳酸氢钠 、 potassium bromide 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 0.33h， 以93%的产率得到12-hydroxyoctadecanal
  参考文献：
  名称：

  用于醇类选择性氧化的金刚烷金刚烷型硝基氧自由基催化剂的开发

  摘要：

  1,5-二甲基-9- azanoradamantane的发展Ñ -1-氧基（DMN-AZADO; 1,5- d我中号乙基Ñ或-AZADO，2），作为伯醇的存在下选择性氧化的有效的催化剂描述了仲醇的混合物。金刚烷金刚烷核的紧密而刚性的结构赋予了DMN-AZADO强大的催化能力（2）。DMN-AZADO（2）将各种受阻伯醇（例如新戊基伯醇）有效地氧化为相应的醛，而仲醇则保持完整。DMN-AZADO（2）对于在仲醇存在下从伯醇到相应的羧酸的一锅法氧化以及从二醇的氧化内酯化反应也具有很高的催化效率。

  DOI：

  10.1021/jo502426p

文献信息

• 9-azanoradamantane N—oxyl compound and method for producing same, and organic oxidation catalyst and method for oxidizing alcohols using 9-azanoradamantane N—oxyl compound
  申请人：TOHOKU UNIVERSITY

  公开号：US09114390B2

  公开（公告）日：2015-08-25

  An organocatalyst for oxidizing alcohols in which a primary alcohol is selectively oxidized in a polyol substrate having a plurality of alcohols under environmentally-friendly conditions. The organic oxidation catalyst has an oxygen atom bonded to a nitrogen atom of an azanoradamantane skeleton and at least one alkyl group at positions 1 and 5. The oxidation catalyst has higher activity than TEMPO, which is an existing oxidation catalyst, in the selective oxidation reaction of primary alcohols, and better selectivity than AZADO and 1-Me-AZADO. This DMN-AZADO can be applied to the selective oxidation reaction of primary alcohols that contributes to shortening the synthesizing process for pharmaceuticals, pharmaceutical raw materials, agricultural chemicals, cosmetics, organic materials, and other such high value-added organic compounds.

  一种有机催化剂，用于在具有多个醇的多元醇基质中选择性氧化初级醇，在环境友好条件下进行。有机氧化催化剂具有氧原子与氮原子结合在氮杂诺伦烷骨架的位置1和5上至少一个烷基团。氧化催化剂在初级醇的选择性氧化反应中比现有氧化催化剂TEMPO具有更高的活性，并且比AZADO和1-Me-AZADO具有更好的选择性。这种DMN-AZADO可以应用于对初级醇的选择性氧化反应，有助于缩短制药、制药原料、农药、化妆品、有机材料等高附加值有机化合物的合成过程。
• Novel acyl-dipeptide-like compounds, a method for preparing the same and pharmaceutical compositions containing such products
  申请人：Bauer Jacques

  公开号：US20060148678A1

  公开（公告）日：2006-07-06

  The invention relates to the field of chemistry and more specifically to the field of medicinal chemistry. The invention is directed to N-acyl-dipeptide-like compounds having the general formula I wherein substituents A, B, X, Y, R 1 , R 2 , and subscripts n, m, p and q have the same meanings as those given in the claims. The invention is equally directed to pharmaceutical compositions containing as an active ingredient at least one compound of general formula I either in acid or salt form with an organic or mineral base. The compounds persuant to the invention display interesting pharmacological properties which make them useful as drugs.

  这项发明涉及化学领域，更具体地涉及药物化学领域。该发明涉及具有通式I的N-酰基二肽类化合物，其中取代基A、B、X、Y、R1、R2以及下标n、m、p和q的含义与索赔中给出的相同。该发明还涉及含有作为活性成分的至少一种通式I化合物的药物组合物，其以有机或矿物质碱的酸或盐形式存在。根据该发明的化合物展示出有趣的药理特性，使它们可用作药物。
• [EN] ACYL RIBONUCLEOSIDES AND ACYL DEOXYRIBONUCLEOSIDES<br/>[FR] RIBONUCLEOSIDES D'ACYLE ET DESOXYRIBONUCLEOSIDES D'ACYLE
  申请人：COGNIS IP MAN GMBH

  公开号：WO2005049633A1

  公开（公告）日：2005-06-02

  The present invention is concerned with acyl ribonucleosides and with acyl deoxyribonucleosides. It is furthermore concerned with an enzymatic process for the manufacture of acyl ribonucleosides and of acyl deoxyribonucleosides. It is furthermore concerned with the use of acyl ribonucleosides and of acyl deoxyribonucleosides for cosmetic and for pharmaceutical purposes and with their use as a food supplement for humans or animals. It is furthermore concerned with compositions containing acyl ribonucleosides and acyl deoxyribonucleosides, whereby these compositions are suitable for cosmetic or for pharmaceutical purposes or as food supplement.

  本发明涉及酰基核糖核苷和酰基脱氧核糖核苷。此外，本发明还涉及一种用于制造酰基核糖核苷和酰基脱氧核糖核苷的酶法过程。此外，本发明还涉及酰基核糖核苷和酰基脱氧核糖核苷在化妆品和药品中的用途，以及它们作为人类或动物的食品补充剂的用途。此外，本发明还涉及含有酰基核糖核苷和酰基脱氧核糖核苷的组合物，这些组合物适用于化妆品或药品或作为食品补充剂。
• Additives and products includings oligoesters
  申请人：Pereira Abel G.

  公开号：US20100035999A1

  公开（公告）日：2010-02-11

  The present invention relates to oligoesters and their use for the creation of additives. Oligoester containing additives and/or oligoesters themselves may be used for formulating pharmaceutical preparations, cosmetics or personal care products such as shampoos and conditioners. These oligoesters are particularly useful for the creation of multi-purpose additives that can impart conditioning, long substantivity and/or UV protection. Individual oligoesters and oligoester mixtures are described.

  本发明涉及寡聚酯及其用于创建添加剂的使用。含有寡聚酯的添加剂和/或寡聚酯本身可用于制定制药制剂、化妆品或个人护理产品，如洗发水和护发素。这些寡聚酯特别适用于创建多功能添加剂，可以赋予调理、长效性和/或紫外线保护。描述了单个寡聚酯和寡聚酯混合物。
• 9-AZANORADAMANTANE N-OXYL COMPOUND AND METHOD FOR PRODUCING SAME, AND ORGANIC OXIDATION CATALYST AND METHOD FOR OXIDIZING ALCOHOLS USING 9-AZANORADAMANTANE N-OXYL COMPOUND
  申请人：TOHOKU UNIVERSITY

  公开号：US20150031887A1

  公开（公告）日：2015-01-29

  An organocatalyst for oxidizing alcohols in which a primary alcohol is selectively oxidized in a polyol substrate having a plurality of alcohols under environmentally-friendly conditions. The organic oxidation catalyst has an oxygen atom bonded to a nitrogen atom of an azanoradamantane skeleton and at least one alkyl group at positions 1 and 5. The oxidation catalyst has higher activity than TEMPO, which is an existing oxidation catalyst, in the selective oxidation reaction of primary alcohols, and better selectivity than AZADO and 1-Me-AZADO. This DMN-AZADO can be applied to the selective oxidation reaction of primary alcohols that contributes to shortening the synthesizing process for pharmaceuticals, pharmaceutical raw materials, agricultural chemicals, cosmetics, organic materials, and other such high value-added organic compounds.

  一种有机催化剂，用于在具有多个醇的多元醇基质中选择性氧化一级醇，以环保条件进行。有机氧化催化剂具有氮杂莫来烷骨架的氧原子与氮原子结合，并且在1和5位置至少有一个烷基基团。在一级醇的选择性氧化反应中，该氧化催化剂比现有的TEMPO具有更高的活性，并且比AZADO和1-Me-AZADO具有更好的选择性。该DMN-AZADO可应用于一级醇的选择性氧化反应，有助于缩短制药、制药原料、农业化学品、化妆品、有机材料等高附加值有机化合物的合成过程。