6-环己氧基吡啶-3-甲醛 | 916792-16-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 6-环己氧基吡啶-3-甲醛
• 英文名称: (6-cyclohexyloxy-pyridin-3-yl)-methaneone
• 英文别名: (6-cyclohexyloxy-pyridin-3-yl)-methanone；6-cyclohexyloxypyridine-3-carboxaldehyde；6-cyclohexyloxypyridine-3-carbaldehyde；6-(Cyclohexyloxy)nicotinaldehyde
• CAS: 916792-16-0
• 化学式: C₁₂H₁₅NO₂
• 分子量: 205.257
• InChiKey: KTDSNAKFASLMHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-环己氧基吡啶-3-甲醛 、 在 溶剂黄146 作用下， 以 二甲基亚砜 为溶剂， 反应 24.0h， 生成
  参考文献：
  名称：

  酪氨酸磷酸酶的靶向蛋白质-蛋白质相互作用与磷酸肽底物支架上显示的微阵列片段文库。

  摘要：

  仅关注催化事件的化学文库筛选方法可能会忽略蛋白质-蛋白质相互作用的独特作用，这种作用可用于开发特定的抑制剂。嵌入肽基序中的磷酸酪氨酰（pTyr）残基包含确定蛋白质酪氨酸磷酸酶（PTPases）底物特异性的最小识别元件。我们将含氨基氧基的氨基酸残基掺入7个残基的表皮生长因子受体（EGFR）衍生的含磷酸酪氨酸的肽中，并使该肽通过与含醛类药物官能团反应而进行溶液相肟多样化。pTyr残基未修饰。将所得的衍生肽文库以微阵列形式印刷在硝酸纤维素涂层的玻璃表面上，以评估PTPase的催化活性，或印刷在金单层上，以通过表面等离振子共振（SPR）分析动力学相互作用。关注氨基酸位置和化学特征，我们首先分析了人双特异性磷酸酶（DUSP）DUSP14和DUSP22以及痘病毒（VH1）和鼠疫耶尔森氏菌（P. YopH）。为了鉴定最高亲和力的肟基序，使用非催化PTPase突变体通过SPR检测了活性最高的衍生化磷酸肽的

  DOI：

  10.1021/acscombsci.8b00122

文献信息

• CYCLOALKYLOXY- AND HETEROCYCLOALKYLOXYPYRIDINE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR
  申请人：Janssen Pharmaceutica, N.V.

  公开号：EP2222664B1

  公开（公告）日：2014-10-29
• ENCAPSULATED BENEFIT AGENT
  申请人：Unilever PLC, A Company Registered in England and Wales under Company no. 41424

  公开号：EP2245132B1

  公开（公告）日：2017-10-18
• Methods and Compositions for Synthesis of Encoded Libraries
  申请人：HitGen Ltd.

  公开号：US20200149034A1

  公开（公告）日：2020-05-14

  Methods of producing compounds and combinatorial compound libraries, the compounds and libraries produced via the methods are provided, and methods of using the libraries to identify compounds having a desired property, such as a desired biological activity and the compounds identified using these methods are provided.
• [EN] ENCAPSULATED BENEFIT AGENT<br/>[FR] AGENT BÉNÉFIQUE ENCAPSULÉ
  申请人：UNILEVER PLC

  公开号：WO2013026620A1

  公开（公告）日：2013-02-28

  A liquid fabric conditioner composition comprising:- (a) a fabric conditioner base comprising a fabric conditioning active and having a pH of from 2.0 to 5.0; and (b) a particle comprising:- (b1) a capsule, which comprises:- (x) a core comprising a benefit agent; and (y) a shell; and (b2) a coating comprising a modified polyvinyl alcohol; wherein the modified polyvinyl alcohol comprises:- (i) a hydrophobic group, selected from an alkyl chain and an aryl chain having from 4 to 16 carbon atoms; and a hydrophilic group which is selected from an alkyl chain and an aryl chain, said hydrophilic group having from 4 to 16 carbon atoms and comprising an amine group selected from a primary, secondary and tertiary amine; and (iii) a mole ratio of hydrophobic groups to hydrophilic groups of from 1:0.5 to 1:10; and wherein the particle has a weight ratio of the capsule to the coating in the range of from 1:1 to 4:1; and the modified polyvinyl alcohol has a level of hydrophobic modification of from 2.0 to 15.0 mole %, with the proviso that at a weight ratio of capsule to coating of about 1:1, preferably from 1:1 to 1.25:1, the level of hydrophobic modification is from 2 to 10 mol %.