1-{1-[5-Chloro-2-(1-thiophen-3-yl-ethoxy)-phenyl]-vinyl}-1H-imidazole | 108649-09-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-{1-[5-Chloro-2-(1-thiophen-3-yl-ethoxy)-phenyl]-vinyl}-1H-imidazole
• 英文别名: 1-[1-[5-Chloro-2-[1-(3-thienyl)ethoxy]phenyl]vinyl]imidazole；1-[1-[5-chloro-2-(1-thiophen-3-ylethoxy)phenyl]ethenyl]imidazole
• CAS: 108649-09-8
• 化学式: C₁₇H₁₅ClN₂OS
• 分子量: 330.838
• InChiKey: BKCFQJSFDAFXNM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  55.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-Chloro-2-(1-imidazol-1-yl-vinyl)-phenol 以40%的产率得到
  参考文献：
  名称：

  OGATA, MASARU;MATSUMOTO, HIROSHI;SHIMIZU, SUMIO;KIDA, SHIRO;SHIRO, MOTOO;+, J. MED. CHEM., 30,(1987) N 8, 1348-1354

  摘要：

  DOI：

文献信息

• Synthesis and antifungal activity of new 1-vinylimidazoles
  作者：Masaru Ogata、Hiroshi Matsumoto、Sumio Shimizu、Shiro Kida、Motoo Shiro、Katsuya Tawara

  DOI：10.1021/jm00391a014

  日期：1987.8

  Carbonyl compounds I were subjected to an imidazole transfer reaction with N,N'-sulfinyldiimidazole or N,N'-carbonyldiimidazole to obtain the diimidazole II and the monoimidazole III. Various 1-vinylimidazoles IV, derived from o-hydroxyacetophenones by imidazole transfer reaction, were alkylated to furnish the title compounds V. The structure-activity relationships of these 1-vinylimidazole compounds V are described.
• OGATA, MASARU;MATSUMOTO, HIROSHI;SHIMIZU, SUMIO;KIDA, SHIRO;SHIRO, MOTOO;+, J. MED. CHEM., 30,(1987) N 8, 1348-1354
  作者：OGATA, MASARU、MATSUMOTO, HIROSHI、SHIMIZU, SUMIO、KIDA, SHIRO、SHIRO, MOTOO、+

  DOI：——

  日期：——