1-(1-{5-Chloro-2-[3-(4-chloro-phenoxy)-propoxy]-phenyl}-2-methyl-propenyl)-1H-imidazole | 77175-28-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-(1-{5-Chloro-2-[3-(4-chloro-phenoxy)-propoxy]-phenyl}-2-methyl-propenyl)-1H-imidazole
• 英文别名: 1-[1-[5-Chloro-2-[3-(4-chlorophenoxy)propoxy]phenyl]-2-methyl-prop-1-enyl]imidazole；1-[1-[5-chloro-2-[3-(4-chlorophenoxy)propoxy]phenyl]-2-methylprop-1-enyl]imidazole
• CAS: 77175-28-1
• 化学式: C₂₂H₂₂Cl₂N₂O₂
• 分子量: 417.335
• InChiKey: IWKXCFWFBCOZNN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  36.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-Chloro-2-(1-imidazol-1-yl-2-methyl-propenyl)-phenol 、 alkaline earth salt of/the/ methylsulfuric acid 在 sodium hydride 作用下， 生成 1-(1-{5-Chloro-2-[3-(4-chloro-phenoxy)-propoxy]-phenyl}-2-methyl-propenyl)-1H-imidazole
  参考文献：
  名称：

  Synthesis and antifungal activity of new 1-vinylimidazoles

  摘要：

  Carbonyl compounds I were subjected to an imidazole transfer reaction with N,N'-sulfinyldiimidazole or N,N'-carbonyldiimidazole to obtain the diimidazole II and the monoimidazole III. Various 1-vinylimidazoles IV, derived from o-hydroxyacetophenones by imidazole transfer reaction, were alkylated to furnish the title compounds V. The structure-activity relationships of these 1-vinylimidazole compounds V are described.

  DOI：

  10.1021/jm00391a014

文献信息

• Synthesis and antifungal activity of new 1-vinylimidazoles
  作者：Masaru Ogata、Hiroshi Matsumoto、Sumio Shimizu、Shiro Kida、Motoo Shiro、Katsuya Tawara

  DOI：10.1021/jm00391a014

  日期：1987.8

  Carbonyl compounds I were subjected to an imidazole transfer reaction with N,N'-sulfinyldiimidazole or N,N'-carbonyldiimidazole to obtain the diimidazole II and the monoimidazole III. Various 1-vinylimidazoles IV, derived from o-hydroxyacetophenones by imidazole transfer reaction, were alkylated to furnish the title compounds V. The structure-activity relationships of these 1-vinylimidazole compounds V are described.