1-[1-(5-Chloro-2-methoxy-phenyl)-vinyl]-1H-imidazole | 108618-05-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-[1-(5-Chloro-2-methoxy-phenyl)-vinyl]-1H-imidazole
• 英文别名: 1-[1-(5-Chloro-2-methoxy-phenyl)vinyl]imidazole；1-[1-(5-chloro-2-methoxyphenyl)ethenyl]imidazole
• CAS: 108618-05-9
• 化学式: C₁₂H₁₁ClN₂O
• 分子量: 234.685
• InChiKey: LWBJLVRIXOMHDF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  27
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-Chloro-2-(1-imidazol-1-yl-vinyl)-phenol 、 碘甲烷 在 sodium hydride 作用下， 生成 1-[1-(5-Chloro-2-methoxy-phenyl)-vinyl]-1H-imidazole
  参考文献：
  名称：

  Synthesis and antifungal activity of new 1-vinylimidazoles

  摘要：

  Carbonyl compounds I were subjected to an imidazole transfer reaction with N,N'-sulfinyldiimidazole or N,N'-carbonyldiimidazole to obtain the diimidazole II and the monoimidazole III. Various 1-vinylimidazoles IV, derived from o-hydroxyacetophenones by imidazole transfer reaction, were alkylated to furnish the title compounds V. The structure-activity relationships of these 1-vinylimidazole compounds V are described.

  DOI：

  10.1021/jm00391a014

文献信息

• Synthesis and antifungal activity of new 1-vinylimidazoles
  作者：Masaru Ogata、Hiroshi Matsumoto、Sumio Shimizu、Shiro Kida、Motoo Shiro、Katsuya Tawara

  DOI：10.1021/jm00391a014

  日期：1987.8

  Carbonyl compounds I were subjected to an imidazole transfer reaction with N,N'-sulfinyldiimidazole or N,N'-carbonyldiimidazole to obtain the diimidazole II and the monoimidazole III. Various 1-vinylimidazoles IV, derived from o-hydroxyacetophenones by imidazole transfer reaction, were alkylated to furnish the title compounds V. The structure-activity relationships of these 1-vinylimidazole compounds V are described.