1-bromobutan-3-ylamine hydrobromide | 94106-02-2

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机溴化物
• 英文名称: 1-bromobutan-3-ylamine hydrobromide
• 英文别名: 4-bromobutan-2-amine hydrobromide；4-bromobutan-2-amine;hydrobromide
• CAS: 94106-02-2
• 化学式: BrH*C₄H₁₀BrN
• 分子量: 232.946
• InChiKey: DUNYJJMVWIDOPH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-bromobutan-3-ylamine hydrobromide 在 sodium sulfite 、 盐酸 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 6.0h， 生成 3-amino-1-butanesulfonic acid
  参考文献：
  名称：

  Methods and compositions for treating amyloid-related diseases

  摘要：

  描述了用于治疗或预防与淀粉样蛋白相关疾病的方法、化合物、药物组合物和试剂盒。

  公开号：

  US20060223855A1
• 作为产物：
  描述：

  3-氨基正丁醇 在 氢溴酸 作用下， 以 水 为溶剂， 反应 6.0h， 生成 1-bromobutan-3-ylamine hydrobromide
  参考文献：
  名称：

  Methods and compositions for treating amyloid-related diseases

  摘要：

  描述了用于治疗或预防与淀粉样蛋白相关疾病的方法、化合物、药物组合物和试剂盒。

  公开号：

  US20060223855A1

文献信息

• [EN] CYCLIC AMIDE DERIVATIVES, AND THEIR PRODUCTION AND USE AS ANTITHROMBOTIC AGENTS<br/>[FR] DÉRIVÉS D'AMIDES CYCLIQUES ET LEUR PRODUCTION ET UTILISATION COMME AGENTS ANTITHROMBOTIQUES
  申请人：TAKEDA PHARMACEUTICAL

  公开号：WO2005113504A1

  公开（公告）日：2005-12-01

  The present invention provides a cyclic amide derivative useful as a drug for treating thrombosis, which is represented by the formula (I): wherein R1 represents an optionally substituted cyclic hydrocarbon group or an optionally substituted heterocyclic group, W represents a bond or an optionally substituted divalent chain hydrocarbon group, a represents 0, 1, or 2, X1 represents an optionally substituted lower alkylene or an optionally substituted lower alkenylene, Y1 represents -C(O)-, -S(O)- or -S(O)2-, A represents a piperazine ring which may be further substituted or a piperidine ring which may be further substituted, X2 represents a bond or an optionally substituted lower alkylene, Y2 represents -C(O)-, -S(O)-, -S(O)2- or -C(=NR7)-, X3 represents an optionally substituted C1-4 alkylene or an optionally substituted C2-4 alkenylene, Z3 represents -N(R4)-, -O- or a bond, Z1 represents -C(R2)(R2')-, -N(R2)-, etc., and Z2 represents -C(R3)(R3')-, -N(R3)-, etc., or a salt thereof.

  本发明提供了一种环酰胺衍生物，可用作治疗血栓症的药物，其化学式为（I）：其中R1代表一个可选择取代的环烃基或一个可选择取代的杂环基，W代表一个键或一个可选择取代的双价链烃基，a代表0、1或2，X1代表一个可选择取代的较低碳烷基或一个可选择取代的较低烯烃基，Y1代表-C（O）-、-S（O）-或-S（O）2-，A代表可能进一步取代的哌嗪环或可能进一步取代的哌啶环，X2代表一个键或一个可选择取代的较低碳烷基，Y2代表-C（O）-、-S（O）-、-S（O）2-或-C（=NR7）-，X3代表一个可选择取代的C1-4烷基或一个可选择取代的C2-4烯烃基，Z3代表-N（R4）-、-O-或一个键，Z1代表-C（R2）（R2'）-、-N（R2）-等，Z2代表-C（R3）（R3'）-、-N（R3）-等，或其盐。
• Cyclic Amide Derivative, and Its Production and Use
  申请人：Kubo Keiji

  公开号：US20070244118A1

  公开（公告）日：2007-10-18

  The present invention provides a cyclic amide derivative useful as a drug for treating thrombosis, which is represented by the formula (I)-: wherein R 1 represents an optionally substituted cyclic hydrocarbon group or an optionally substituted heterocyclic group, W represents a bond or an optionally substituted divalent chain hydrocarbon group, a represents 0, 1, or 2, X 1 represents an optionally substituted lower alkylene or an optionally substituted lower alkenylene, Y 1 represents —C(O)—, —S(O)— or —S(O) 2 —, A represents a piperazine ring which may be further substituted or a piperidine ring which may be further substituted, X 2 represents a bond or an optionally substituted lower alkylene, Y 2 represents —C(O)—, —S(O)—, —S(O) 2 — or —C(═NR 7 )—, X 3 represents an optionally substituted C 1-4 alkylene or an optionally substituted C 2-4 alkenylene, Z 3 represents —N(R 4 )—, —O— or a bond, Z 1 represents —C(R 2 )(R 2′ )—, —N(R 2 )—, etc., and Z 2 represents —C(R 3 )(R 3′ )—, —N(R 3 )—, etc., or a salt thereof.

  本发明提供了一种环酰胺衍生物，用作治疗血栓的药物，其化学式表示为(I)-:其中R1表示可选取代的环烃基或可选取代的杂环基，W表示键或可选取代的二价链烃基，a表示0、1或2，X1表示可选取代的较低烷基或可选取代的较低烯基，Y1表示—C(O)—、—S(O)—或—S(O)2—，A表示可进一步取代的哌嗪环或可进一步取代的哌啶环，X2表示键或可选取代的较低烷基，Y2表示—C(O)—、—S(O)—、—S(O)2—或—C(═NR7)—，X3表示可选取代的C1-4烷基或可选取代的C2-4烯基，Z3表示—N(R4)—、—O—或键，Z1表示—C(R2)(R2′)—、—N(R2)—等，Z2表示—C(R3)(R3′)—、—N(R3)—等，或其盐。
• Cyclic amide derivative, and its production and use
  申请人：Kubo Keiji

  公开号：US20080255352A1

  公开（公告）日：2008-10-16

  The present invention provides a cyclic amide derivative useful as a drug for treating thrombosis, which is represented by the formula (I): wherein R 1 represents an optionally substituted cyclic hydrocarbon group or an optionally substituted heterocyclic group, W represents a bond or an optionally substituted divalent chain hydrocarbon group, a represents 0, 1, or 2, X 1 represents an optionally substituted lower alkylene or an optionally substituted lower alkenylene, Y 1 represents —C(O)—, —S(O)— or —S(O) 2 —, A represents a piperazine ring which may be further substituted or a piperidine ring which may be further substituted, X 2 represents a bond or an optionally substituted lower alkylene, Y 2 represents —C(O)—, —S(O)—, —S(O) 2 — or —C(═NR 7 )—, X 3 represents an optionally substituted C 1-4 alkylene or an optionally substituted C 2-4 alkenylene, Z 3 represents —N(R 4 )—, —O— or a bond, Z 1 represents —C(R 2 )(R 2′ )—, —N(R 2 )—, etc., and Z 2 represents —C(R 3 )(R 3′ )—, —N(R 3 )—, etc., or a salt thereof.

  本发明提供了一种用于治疗血栓症的环酰胺衍生物，其化学式表示为(I)：其中，R1代表可选取代的环烃基或可选取代的杂环基，W代表键或可选取代的双价链烃基，a代表0、1或2，X1代表可选取代的较低烷基烯基或可选取代的较低烷基，Y1代表—C（O）—、—S（O）—或—S（O）2—，A代表可进一步取代的哌嗪环或可进一步取代的吡啶环，X2代表键或可选取代的较低烷基，Y2代表—C（O）—、—S（O）—、—S（O）2—或—C（═NR7）—，X3代表可选取代的C1-4烷基或可选取代的C2-4烯基，Z3代表—N（R4）—、—O—或键，Z1代表—C（R2）（R2′）—、—N（R2）—等，Z2代表—C（R3）（R3′）—、—N（R3）—等，或其盐。
• CYCLIC AMIDE DERIVATIVE, AND ITS PRODUCTION AND USE
  申请人：KUBO Keiji

  公开号：US20100160629A1

  公开（公告）日：2010-06-24

  The present invention provides a cyclic amide derivative useful as a drug for treating thrombosis, which is represented by the formula (I): wherein R 1 represents an optionally substituted cyclic hydrocarbon group or an optionally substituted heterocyclic group, W represents a bond or an optionally substituted divalent chain hydrocarbon group, a represents 0, 1, or 2, X 1 represents an optionally substituted lower alkylene or an optionally substituted lower alkenylene, Y 1 represents —C(O)—, —S(O)— or —S(O) 2 —, A represents a piperazine ring which may be further substituted or a piperidine ring which may be further substituted, X 2 represents a bond or an optionally substituted lower alkylene, Y 2 represents —C(O)—, —S(O)—, —S(O) 2 — or —C(═NR 7 )—, X 3 represents an optionally substituted C 1-4 alkylene or an optionally substituted C 2-4 alkenylene, Z 3 represents —N(R 4 )—, —O— or a bond, Z 1 represents —C(R 2 )(R 2′ )—, —N(R 2 )—, etc., and Z 2 represents —C(R 3 )(R 3′ )—, —N(R 3 )—, etc., or a salt thereof.

  本发明提供了一种环酰胺衍生物，可用作治疗血栓症的药物，其化学式为(I)，其中R1代表可选取代的环烃基或可选取代的杂环基，W代表键或可选取代的二价链烃基，a代表0、1或2，X1代表可选取代的较低烷基或可选取代的较低烯基，Y1代表—C(O)—、—S(O)—或—S(O)2—，A代表可能进一步取代的哌嗪环或可能进一步取代的哌啶环，X2代表键或可选取代的较低烷基，Y2代表—C(O)—、—S(O)—、—S(O)2—或—C(═NR7)—，X3代表可选取代的C1-4烷基或可选取代的C2-4烯基，Z3代表—N(R4)—、—O—或键，Z1代表—C(R2)(R2′)—、—N(R2)—等，Z2代表—C(R3)(R3′)—、—N(R3)—等，或其盐。
• Synthesis of S-(3-aminobutyl)isothiourea and its heterocyclic derivative and radioprotective effect of these compounds
  作者：G. V. Dontsova、M. M. Konstantinova、A. A. Mandrugin、O. N. Rakhmanina、V. M. Fedoseev、Yu. V. Shlykov

  DOI：10.1007/bf00758568

  日期：1986.3