6-甲基-2-丙基-吡啶-3-醇 | 5377-23-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 6-甲基-2-丙基-吡啶-3-醇
• 英文名称: 6-methyl-2-propyl-pyridin-3-ol
• 英文别名: 2-Methyl-6-propyl-pyridin-3-ol；6-Methyl-2-propylpyridin-3-ol
• CAS: 5377-23-1
• 化学式: C₉H₁₃NO
• 分子量: 151.208
• InChiKey: VQHMRTNEYXIKSJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  33.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-甲基-2-丙基-吡啶-3-醇 、 4-fluoro-N-(3,4,5-trimethoxyphenyl)pyridin-2-amine 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.25h， 以47%的产率得到4-(6-methyl-2-propylpyridin-3-yloxy)-N-(3,4,5-trimethoxyphenyl)pyridin-2-amine
  参考文献：
  名称：

  CHEMICAL COMPOUNDS-821

  摘要：

  该发明涉及化学式(I)的化合物，或其药学上可接受的盐，具有ALK5（TGFβR1）抑制活性，因此在抗癌活性方面有用，从而在治疗人体或动物体的方法中有用。该发明还涉及制造上述化学化合物的方法，含有它们的药物组合物，以及它们在制造用于在温血动物（如人）中产生抗癌效果的药物中的使用。

  公开号：

  US20090048269A1
• 作为产物：
  描述：

  4-{[4-(6-ethyl-2-pyridin-2-yl-pyridin-3-yl)oxypyridin-2-yl]-amino}benzene-sulfonamide 在 钯 氢气 作用下， 以 乙醇 为溶剂， 25.0 ℃ 、13.51 MPa 条件下， 反应 1.5h， 以to provide the title compound (407 mg, 98%) as a white solid的产率得到6-甲基-2-丙基-吡啶-3-醇
  参考文献：
  名称：

  CHEMICAL COMPOUNDS-821

  摘要：

  本发明涉及公式（I）的化合物或其药学上可接受的盐，具有ALK5（TGFβR1）抑制活性，因此在抗癌活性和人或动物体的治疗方法中有用。本发明还涉及制造上述化合物的方法，含有它们的制药组合物以及它们在制造用于在温血动物（如人）中产生抗癌效果的药物的制剂中的使用。

  公开号：

  US20090048269A1

文献信息

• 1,3-Dihydro-Benzimidazol-2-Ylidene Amines as Inhibitors of Respiratory Syncytial Virus Replication
  申请人：Bonfanti Jean-Francois

  公开号：US20080146564A1

  公开（公告）日：2008-06-19

  Novel 1,3-dihydro-benzimidazol-2-ylidene amine derivatives of formula the addition salts and stereochemically isomeric forms wherein each Alk is C 1-6 alkanediyl; Q is hydrogen; C 1-6 alkyl substituted with one or two Ar 2 radicals; CI 1-6 alkyl substituted with quinolinyl, oxazolidinyl, thiazolidinyl, morpholinyl, thiomorpholinyl, or with pyrrolidinonyl; —CO—Ar 2 ; or Q is a radical of formula wherein t is 1, 2 or 3; R 4 is amino, mono- or di(C 1-6 alkyl)amino; R 1 is Ar 2 , —CO—Ar 2 or a monocyclic or bicyclic heterocycle which may optionally be substituted; R 2 is as R 1 and additionally can be hydrogen; where Q is other than hydrogen, R 3 is hydrogen; and where Q is other than hydrogen, R 3 is a radical: wherein R 6 is hydrogen, C 1-6 alkyl, substituted C 1-6 alkyl; R 7 , R 8 , R 9 are halo, cyano, C 1-6 alkyl, substituted C 1-6 alkyl, C 2-6 alkenyl, cyanoC 2-6 alkenyl, C 2-6 alkynyl, cyanoC 2 6 alkynyl, Ar 1 , R 10a —0—, R 10a —S—, —N(R 5a R 5b ), R 10a —O—C(═O)—, N(R 5a R 5b )—C(═O)—, R 10a —C(═O)—NR 5b 1', R 10b —C(═O)—O—; and R 8 and/or R 9 may also be hydrogen; which are RSV inhibitors. Compositions containing these compounds and processes for preparing these compounds and compositions.
• TETRA- AND PENTASUBSTITUTED BENZIMIDAZOLIUM COMPOUNDS USEFUL IN THE TREATMENT OF RESPIRATORY DISEASES
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20180002312A1

  公开（公告）日：2018-01-04

  The present invention relates to compounds of formula (I), or the tautomers or pharmacologically acceptable acid addition salts thereof, wherein R 1 , R 2 , R 3 , R 4 , X, and Z have one of the meanings as defined in the specification, to the use of compounds of formula (I) as a medicament, to pharmaceutical composition comprising at least one compound of formula (I), as well as to medicament combinations containing one or more compounds of formula (I).
• SUBSTITUTED BENZIMIDAZOLIUM COMPOUNDS USEFUL IN THE TREATMENT OF RESPIRATORY DISEASES
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20180009789A1

  公开（公告）日：2018-01-11

  The present invention relates to compounds of formula (I), or the tautomers or pharmacologically acceptable acid addition salts thereof, wherein R 1 , R 2 , R 3 , R 4 , X, and Z have one of the meanings as defined in the specification, to the use of compounds of formula (I) as a medicament, to pharmaceutical composition comprising at least one compound of formula (I), as well as to medicament combinations containing one or more compounds of formula (I).
• US7956196B2
  申请人：——

  公开号：US7956196B2

  公开（公告）日：2011-06-07
• US9932324B2
  申请人：——

  公开号：US9932324B2

  公开（公告）日：2018-04-03