2-N-benzyl-3-[2-(4-methoxyphenyl)ethyl]-7-methyl-6-N-(5-methyl-1,2-oxazol-3-yl)-4-oxo-10-oxa-3-azatricyclo[5.2.1.01,5]dec-8-ene-2,6-dicarboxamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-N-benzyl-3-[2-(4-methoxyphenyl)ethyl]-7-methyl-6-N-(5-methyl-1,2-oxazol-3-yl)-4-oxo-10-oxa-3-azatricyclo[5.2.1.01,5]dec-8-ene-2,6-dicarboxamide
• 化学式: C₃₁H₃₂N₄O₆
• 分子量: 556.6
• InChiKey: YWYSKVPJMJYVBI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  41
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  123
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Alpha-helix mimetics and method relating to the treatment of cancer stem cells
  申请人：Kahn Michael

  公开号：US20070129353A1

  公开（公告）日：2007-06-07

  The invention provides α-mimetic structures and a chemical library relating thereto. Additionally, the invention provides methods wherein a-mimetic compounds are used to treat cancer stem cells.

  该发明提供了α-类似物结构和相关的化学库。此外，该发明提供了使用α-类似化合物治疗癌症干细胞的方法。
• ALFA-HELIX MIMETICS AND METHOD RELATING TO THE TREATMENT OF CANCER STEM CELLS
  申请人：Choongwae Pharma Corporation

  公开号：EP1957516B1

  公开（公告）日：2016-03-09
• Alpha-helix mimetics and methods relating to the treatment of fibrotic disorders
  申请人：Kahn Michael

  公开号：US20080009500A1

  公开（公告）日：2008-01-10

  The invention provides α-mimetic structures and a chemical library relating thereto. Additionally, the invention provides methods wherein α-mimetic compounds are used to treat fibrotic disorders.