1-(Diaminomethylidene)-2-(3-phenoxypropoxy)guanidine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-(Diaminomethylidene)-2-(3-phenoxypropoxy)guanidine
• 英文别名: 1-(diaminomethylidene)-2-(3-phenoxypropoxy)guanidine
• 化学式: C₁₁H₁₇N₅O₂
• 分子量: 251.29
• InChiKey: JXLVXFBOYQYRKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  121
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Ligand/binding partner bio-labeling systems
  申请人：Cornish Virginia

  公开号：US20060211007A1

  公开（公告）日：2006-09-21

  The present invention relates to methods and compositions which utilize binding relationships between detector molecules and their ligands for labeling molecules of interest in vivo. A “target” molecule is linked to a detector molecule (such as a protein or a nucleic acid) and the function and/or location of the target molecule is monitored by binding the detector molecule its ligand, which carries a detectable label. In particular embodiments of the invention, an intracellular fusion protein comprising a target protein and a detector protein is bound to a membrane-permeable, fluorescently-labeled ligand of the detector protein, thereby providing an adjunct or alternative to Green Fluorescent Protein.

  本发明涉及利用检测器分子与其配体之间的结合关系来标记体内相关分子的方法和组合物。目标 "分子与检测器分子（如蛋白质或核酸）相连，通过检测器分子与其配体的结合来监测目标分子的功能和/或位置，配体上带有可检测的标签。在本发明的特定实施方案中，由目标蛋白和检测蛋白组成的细胞内融合蛋白与检测蛋白的膜渗透性荧光标记配体结合，从而提供了绿色荧光蛋白的辅助或替代物。
• EP1601576A4
  申请人：——

  公开号：EP1601576A4

  公开（公告）日：2007-12-05
• LIGAND/BINDING PARTNER BIO-LABELING SYSTEMS
  申请人：The Trustees of Columbia University in the City of New York

  公开号：EP1601576A2

  公开（公告）日：2005-12-07
• US7575866B2
  申请人：——

  公开号：US7575866B2

  公开（公告）日：2009-08-18
• [EN] LIGAND/BINDING PARTNER BIO-LABELING SYSTEMS<br/>[FR] SYSTEMES DE BIOMARQUAGE LIGAND/PARTENAIRE DE LIAISON
  申请人：UNIV COLUMBIA

  公开号：WO2004078594A2

  公开（公告）日：2004-09-16

  The present invention relates to methods and compositions which utilize binding relationships between detector molecules and their ligands for labeling molecules of interest in vivo. A 'target' molecule is linked to a detector molecule (such as a protein or a nucleic acid) and the function and/or location of the target molecule is monitored by binding the detector molecule its ligand, which carries a detectable label. In particular embodiments of the invention, an intracellular fusion protein comprising a target protein and a detector protein is bound to a membrane-permeable, fluorescently-labeled ligand of the detector protein, thereby providing an adjunct or alternative to Green Fluorescent Protein.