12-[6,8-Bis(sulfanyl)octanoyloxy]dodecyl 6,8-bis(sulfanyl)octanoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 12-[6,8-Bis(sulfanyl)octanoyloxy]dodecyl 6,8-bis(sulfanyl)octanoate
• 英文别名: 12-[6,8-bis(sulfanyl)octanoyloxy]dodecyl 6,8-bis(sulfanyl)octanoate
• 化学式: C₂₈H₅₄O₄S₄
• 分子量: 583.0
• InChiKey: WADHZWZFTLBUFR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.7
• 重原子数：
  36
• 可旋转键数：
  29
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  56.6
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• ANTIOXIDANT CAMPTOTHECIN DERIVATIVES AND ANTIOXIDANT ANTINEOPLASTIC NANOSPHERES THEREOF
  申请人：Cedars-Sinai Medical Center

  公开号：EP2370435B1

  公开（公告）日：2015-01-07
• [EN] ANTIOXIDANT, ANTI-INFLAMMATORY AND ANTICANCER DERIVATIVES OF TRIPTOLIDE AND NANOSPHERES THEREOF<br/>[FR] DÉRIVÉS ANTIOXYDANTS, ANTI-INFLAMMATOIRES ET ANTICANCÉREUX DU TRIPTOLIDE ET NANOSPHÈRES À BASE DE CEUX-CI
  申请人：CEDARS SINAI MEDICAL CENTER

  公开号：WO2014201026A2

  公开（公告）日：2014-12-18

  This invention relates to uses of conjugates of triptolide nanoprodrugs in cancer immunotherapy, specifically compound such as D-I or D-II wherein X1 is a antioxidant, an anti-inflammatory or an anticancer agent and nanospheres thereof, and A is be selected from the group consisting of branched and unbranched alkyl, branched and unbranched alkenyl, branched and unbranched alkynyl, heteroatom-containing branched and unbranched alkyl, heteroatom-containing branched and unbranched alkenyl, heteroatom-containing branched and unbranched alkynyl, aryl, cyclic aliphatic, cyclic aromatic, heterocyclic, and aromatic heterocyclic groups.