申请人:The Board of Trustees of the Leland Stanford Junior University
公开号:US10114004B2
公开(公告)日:2018-10-30
A method of analyzing a population of cells is disclosed. In certain embodiments, the method includes i) obtaining an array of cells on a substrate, wherein the cells are labeled with one or more mass tags and are separated from one another, ii) measuring, using secondary ion mass spectrometry (SIMS), the abundance of the one or more mass tags at a plurality of locations occupied by the cells, thereby generating, for each individual cell measured, a set of data, and iii) outputting the set of data for each of the cells analyzed. Also provided herein are systems that find use in performing the subject method. In some embodiments, the system is an automated system for analyzing a population of cells using SIMS.
本发明公开了一种分析细胞群的方法。在某些实施方案中,该方法包括 i) 在基底上获得细胞阵列,其中细胞用一个或多个质量标签标记并相互分离;ii) 使用二次离子质谱法(SIMS)测量细胞占据的多个位置上一个或多个质量标签的丰度,从而为测量的每个单个细胞生成一组数据;iii) 为分析的每个细胞输出这组数据。本文还提供了可用于执行所述方法的系统。在某些实施方案中,该系统是使用 SIMS 分析细胞群的自动化系统。