(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(3S,12S,15S,18S,21R,24S,26R)-21-benzyl-18-(3-carbamimidamidopropyl)-12-carbamoyl-26-hydroxy-15-(1H-indol-3-ylmethyl)-2,6,14,17,20,23-hexaoxo-1,7,13,16,19,22-hexazabicyclo[22.3.0]heptacosan-3-yl]amino]-1-oxohexan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-2-[[(2S)-3-hydroxy-2-[[2-[(4-oxocyclohexanecarbonyl)amino]acetyl]amino]propanoyl]amino]pentanediamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(3S,12S,15S,18S,21R,24S,26R)-21-benzyl-18-(3-carbamimidamidopropyl)-12-carbamoyl-26-hydroxy-15-(1H-indol-3-ylmethyl)-2,6,14,17,20,23-hexaoxo-1,7,13,16,19,22-hexazabicyclo[22.3.0]heptacosan-3-yl]amino]-1-oxohexan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-2-[[(2S)-3-hydroxy-2-[[2-[(4-oxocyclohexanecarbonyl)amino]acetyl]amino]propanoyl]amino]pentanediamide
• 化学式: C₇₄H₁₀₅N₂₁O₁₉
• 分子量: 1592.8
• InChiKey: HASMLVZETRYJFT-JBGBHXSJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.7
• 重原子数：
  114
• 可旋转键数：
  34
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  640
• 氢给体数：
  22
• 氢受体数：
  21

文献信息

• Trimeric Peptides for Use in Treating Obesity
  申请人：Conde Frieboes Kilian Waldemar

  公开号：US20080200366A1

  公开（公告）日：2008-08-21

  The present invention relates to novel peptide compounds which are effective in modulating one or more melanocortin receptor types, to the use of the compounds in therapy, to methods of treatment comprising administration of the compounds to patients in need thereof, and to the use of the compounds in the manufacture of medicaments. The compounds of the invention are of particular interest in relation to the treatment of obesity as well as a variety of diseases or conditions associated with obesity.

  本发明涉及新型肽化合物，其在调节一个或多个黑色素皮质素受体类型方面具有有效性，涉及将这些化合物用于治疗，涉及包括向需要这些化合物的患者进行给药的治疗方法，以及涉及将这些化合物用于制造药物。本发明的化合物在治疗肥胖以及与肥胖相关的各种疾病或病况方面具有特别兴趣。
• Multimers of Peptides
  申请人：Conde Fieboes Killian Waldemar

  公开号：US20080305986A1

  公开（公告）日：2008-12-11

  Described are compounds useful for trimerising chemical entities, methods of trimerising chemical entities, and trimerised entities. In one aspect, the entities are peptides.