3-Methyl-2-[(3-methylphenyl)methylazaniumyl]pentanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-Methyl-2-[(3-methylphenyl)methylazaniumyl]pentanoate
• 化学式: C14H21NO2
• mdl: MFCD03450347
• 分子量: 235.32
• InChiKey: DFCDGYOQLIZVMK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• KIT COMPRISING IGF-1R ANTIBODY-DRUG-CONJUGATE AND ITS USE FOR THE TREATMENT OF CANCER
  申请人：PIERRE FABRE MEDICAMENT

  公开号：EP3498301A1

  公开（公告）日：2019-06-19

  The present invention relates to an antibody-drug-conjugate capable of binding IGF-1R. From one aspect, the invention relates to an antibody-drug-conjugate comprising an antibody capable of binding to IGF-1R, said antibody being conjugated to at least one drug selected from derivatives of dolastatin 10 and auristatins. The invention also comprises method of treatment and the use of said antibody-drug-conjugate for the treatment of cancer.

  本发明涉及一种能够结合 IGF-1R 的抗体-药物-轭合物。从一个方面来说，本发明涉及一种抗体-药物-轭合物，它包括一种能够与 IGF-1R 结合的抗体，所述抗体与至少一种选自多拉他汀 10 和曙红的衍生物的药物结合。本发明还包括治疗癌症的方法和使用所述抗体-药物共轭物的方法。
• ANTIBODY-DRUG-CONJUGATE AND ITS USE FOR THE TREATMENT OF CANCER
  申请人：PIERRE FABRE MEDICAMENT

  公开号：EP3607996A1

  公开（公告）日：2020-02-12

  The present invention relates to an antibody-drug-conjugate. From one aspect, the invention relates to an antibody-drug-conjugate comprising an antibody capable of binding to a Target, said antibody being conjugated to at least one drug selected from derivatives of dolastatin 10 and auristatins. The invention also comprises method of treatment and the use of said antibody-drug-conjugate for the treatment of cancer.

  本发明涉及一种抗体-药物共轭物。从一个方面来看，本发明涉及一种抗体-药物-共轭物，该抗体-药物-共轭物包含一种能够与靶标结合的抗体，所述抗体与至少一种选自多拉他汀 10 和曙红的衍生物的药物共轭。本发明还包括治疗癌症的方法和使用所述抗体-药物-共轭物的方法。
• DERIVATIVES OF DOLASTATIN 10 AND AURISTATINS
  申请人：Pierre Fabre Médicament

  公开号：EP2989088B1

  公开（公告）日：2017-09-27
• IGF-1R ANTIBODY-DRUG-CONJUGATE AND ITS USE FOR THE TREATMENT OF CANCER
  申请人：Pierre Fabre Médicament

  公开号：EP3134124B1

  公开（公告）日：2019-02-20