9-bromoheptadecane | 114813-41-1

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机溴化物
• 英文名称: 9-bromoheptadecane
• 英文别名: Dioctylbrommethan；9-Brom-heptadecan
• CAS: 114813-41-1
• 化学式: C₁₇H₃₅Br
• 分子量: 319.369
• InChiKey: HTAQNPJTWUXABQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9
• 重原子数：
  18
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  9-bromoheptadecane 在 甲醇 、 sodium methylate 作用下， 以 乙腈 为溶剂， 反应 26.0h， 生成 9-heptadecanethiol
  参考文献：
  名称：

  用于递送核酸的阳离子脂质化合物和组合物及用途

  摘要：

  本发明提供了用于递送核酸的阳离子脂质化合物和组合物及用途。所述化合物如下式（I）所示。本发明还提供了以所述化合物为关键组分的纳米脂质颗粒在核酸递送方面的用途，包含递送载体的组分、制备方法和使用方法。（I）。

  公开号：

  CN114989027B
• 作为产物：
  描述：

  十七烷-9-醇 在 四溴化碳 、 三苯基膦 作用下， 以 二氯甲烷 为溶剂， 以84%的产率得到9-bromoheptadecane
  参考文献：
  名称：

  用于递送核酸的阳离子脂质化合物和组合物及用途

  摘要：

  本发明提供了用于递送核酸的阳离子脂质化合物和组合物及用途。所述化合物如下式（I）所示。本发明还提供了以所述化合物为关键组分的纳米脂质颗粒在核酸递送方面的用途，包含递送载体的组分、制备方法和使用方法。（I）。

  公开号：

  CN114989027B

文献信息

• 一种脂质化合物及脂质体与药物组合物
  申请人：纳肽得（青岛）生物医药有限公司

  公开号：CN114763324A

  公开（公告）日：2022-07-19

  本发明涉及一种脂质化合物，具体的提供了一种具有式(Ⅰ)所示结构的脂质化合物，式(Ⅰ)如下所示：其中，A为N或CH；X、Y、Z各自独立地选自与A连接的碳原子或碳链的化学基团；本发明提出了用于转染细胞的脂质化合物、脂质体及其在核酸等治疗剂运载和制备药物中的用途以及药物组合物，该脂质化合物可以高效递送核酸分子进入细胞，进入细胞后释放核酸分子，从而发挥核酸分子相应的功能，尤其适用于siRNA，通过RNA干扰达到基因沉默的目的，最终治疗疾病。
• Granet, Robert; Piekarski, Salomon, Journal de Chimie Physique et de Physico-Chimie Biologique, 1986, vol. 83, # 2, p. 131 - 136
  作者：Granet, Robert、Piekarski, Salomon

  DOI：——

  日期：——
• Design and Synthesis of 4,6-Di-<i>tert</i>-butyl-2,3-dihydro-5-benzofuranols as a Novel Series of Antiatherogenic Antioxidants
  作者：Kunio Tamura、Yoshiaki Kato、Akira Ishikawa、Yasuharu Kato、Motomu Himori、Mitsutaka Yoshida、Yoshiaki Takashima、Tsukasa Suzuki、Yoshiki Kawabe、Osamu Cynshi、Tatsuhiko Kodama、Etsuo Niki、Makoto Shimizu

  DOI：10.1021/jm030062a

  日期：2003.7.1

  Antioxidants have been considered as potential antiatherogenic agents by inhibiting oxidation of low-density lipoprotein (LDL), albeit vitamin E, a natural antioxidant, has failed to show reduction on atherosclerosis in clinical trials. We have rationally designed and synthesized a novel series of antioxidants, 4,6-di-tert-butyl-2,3-dihydro-5-benzofuranols, to overcome the clinical limitation of vitamin E. In vitro, the compounds showed a potent inhibitory effect on lipid peroxidation detected as 2-methyl-6-(p-methoxyphenyl)-3,7-dihydroimidazo[1,2-a]pyrazin3-one (MCLA)-dependent chemiluminescence in linoleic acid autoxidation. They also inhibited the LDL oxidation induced by Cu2+, and the inhibition is more potent than that of vitamin E and probucol. In vivo, 4,6-di-tert-butyl-2,3-dihydro-2,2-dipentyl-5-benzofuranoI (BO-653, 1f), an optimal compound, showed the highest concentration in plasma and LDL fraction in Watanabe heritable hyperlipidemic rabbits, due to its high affinity to LDL. The isolated LDL samples from the If-treated rabbits showed potent resistibility to LDL oxidation. Compound If has been taken into clinical trials.
• Synthesis and biological evaluation of galactofuranosyl alkyl thioglycosides as inhibitors of mycobacteria
  作者：Chris B. Davis、Regan D. Hartnell、Paul D. Madge、David J. Owen、Robin J. Thomson、Andrew K.J. Chong、Ross L. Coppel、Mark von Itzstein

  DOI：10.1016/j.carres.2007.04.027

  日期：2007.9

  As part of our research interest directed toward the development of antimycobacterial agents, we have investigated compounds based on galactofuranose (Galf), an essential cell wall component of mycobacteria. The objective of this study was to explore structure activity relationships of Galf thioglycosides with straight chain and branched aglycons. Acylated Galf 9-heptadecyl thioglycoside was prepared by Lewis acid-catalyzed thioglycosidation of 1, 2,3,5,6-penta-O-acyl-D-galactofuranose with 9-heptadecanethiol, and subsequently converted to the corresponding sulfone using m-CPBA. Both Galf 9-heptadecyl thioglycoside and sulfone displayed in vitro inhibition (MIC) of the growth of Mycobacterium smegmatis below 5 mu g/mL, while Galf 1-octyl thioglycoside gave no inhibition at or below 32 mu g/mL. (c) 2007 Elsevier Ltd. All rights reserved.
• Family of Diazapentalene Chromophores and Narrow-Band-Gap Polymers: Synthesis, Halochromism, Halofluorism, and Visible–Near Infrared Photodetectivity
  作者：Gang Qian、Ji Qi、James A. Davey、James S. Wright、Zhi Yuan Wang

  DOI：10.1021/cm300938s

  日期：2012.6.26

  A family of pyrrolo[3,4-c]pyrrol-1(2H)-one (PPO) and 2,5-diazapentalene (DAP) chromophores and DAP-containing polymers were synthesized, and their optical and electrochemical properties were studied. PPO and DAP chromophores are readily obtained by chemical transformation of the lactam unit in diketopyrrolopyrrole (DPP) dyes and can be used as versatile building blocks for construction of a variety of conjugated low-band-gap compounds and polymers. In comparison with the DPP chromophores, PPO and DAP chromophores have narrower energy gaps and low-lying HOMO levels in the order DPP > PPO > DAP. Interestingly, the PPO and DAP chromophores exhibit unique visible and near-infrared halochromic and halofluoric properties. The emission spectrum of DAP-containing polymer 6d covers the telecommunication window including the wavelength of 1310 nm. The photodetector with a device configuration of ITO/PEDOT:PSS (35 nm)/active layer (100 nm)/Al (100 nm) was fabricated using a blend of polymer 6d and [6,6]-phenyl-C-61-butyric acid methyl ester (PC61BM) in a weight ratio of 1:3 as the active layer and exhibited photocurrent spectral response from 400 to 1000 nm and the detectivity in an order of 10(11) Jones at 800 nm.