4-{[5-(Thiophen-2-yl)-1,2-oxazol-3-yl]carbonyl}morpholine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 4-{[5-(Thiophen-2-yl)-1,2-oxazol-3-yl]carbonyl}morpholine
• 英文别名: morpholin-4-yl-(5-thiophen-2-yl-1,2-oxazol-3-yl)methanone
• 化学式: C₁₂H₁₂N₂O₃S
• mdl: MFCD09782551
• 分子量: 264.3
• InChiKey: PGCWRGGPXZFLAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  83.8
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Chemical inducers of neurogenesis
  申请人：Schneider Jay

  公开号：US20090036451A1

  公开（公告）日：2009-02-05

  The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The methods may take place in vitro, such as in isolates from the adult mammalian brain, or in vivo. Compounds and methods described herein may find use in the treatment of neurodegenerative and psychiatric diseases, the repair and regeneration of the nervous system, and in treatment of neurologic malignancy.

  本发明涉及化合物和方法，用于诱导正常神经干细胞和脑癌干细胞的神经元分化。这些方法可以在体外进行，例如在成年哺乳动物大脑的分离物中，或在体内进行。本文描述的化合物和方法可能在治疗神经退行性和精神疾病、神经系统的修复和再生以及神经逻辑恶性肿瘤的治疗中发挥作用。
• CHEMICAL INDUCERS OF NEUROGENESIS
  申请人：Schneider Jay

  公开号：US20130143885A1

  公开（公告）日：2013-06-06

  The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The methods may take place in vitro, such as in isolates from the adult mammalian brain, or in vivo. Compounds and methods described herein may find use in the treatment of neurodegenerative and psychiatric diseases, the repair and regeneration of the nervous system, and in treatment of neurologic malignancy.

  本发明涉及化合物和方法，用于诱导正常神经干细胞和脑癌干细胞的神经元分化。这些方法可以在体外进行，例如从成年哺乳动物大脑中分离出来，也可以在体内进行。本文所描述的化合物和方法可以在神经退行性和精神疾病的治疗、神经系统的修复和再生以及神经逻辑恶性肿瘤的治疗中发挥作用。
• COMPOUNDS THAT INCREASE TELOMERASE REVERSE TRANSCRIPTASE (TERT) EXPRESSION AND METHODS FOR USING THE SAME
  申请人：Andrews William H.

  公开号：US20090143451A1

  公开（公告）日：2009-06-04

  Compounds, and methods of using the same, are provided which increase the expression of telomerase reverse transcriptase (TERT) in a cell. These compounds and methods find use in a variety of applications in which increased expression of telomerase is desired, including immortalization of cell lines and treating conditions in a subject characterized by cellular senescence.
• US8193225B2
  申请人：——

  公开号：US8193225B2

  公开（公告）日：2012-06-05
• US8778940B2
  申请人：——

  公开号：US8778940B2

  公开（公告）日：2014-07-15