methyl (5S,12R,18R)-5,12,18-trihydroxyicosa-6,8,10,14,16-pentaenoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: methyl (5S,12R,18R)-5,12,18-trihydroxyicosa-6,8,10,14,16-pentaenoate
• 化学式: C₂₁H₃₂O₅
• 分子量: 364.5
• InChiKey: RGORHHTZBFPFQX-HSALFYBXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  26
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• TRIHYDROXY POLYUNSATURATED EICOSANOID DERIVATIVES
  申请人：UNIVERSITY OF SOUTHERN CALIFORNIA

  公开号：EP1863753B1

  公开（公告）日：2017-09-20
• Trihydroxy Polyunsaturated Eicosanoid
  申请人：Petasis Nicos A.

  公开号：US20090291916A1

  公开（公告）日：2009-11-26

  The invention features methods for the preparation of naturally occurring trihydroxy polyunsaturated eicosanoids and their structural analogs. The invention further provides new derivatives and analogs of trihydroxy polyunsaturated eicosanoids that can be prepared according to these methods. The invention also provides compositions and methods using trihydroxy polyunsaturated eicosanoid derivatives for the prevention, amelioration and treatment of a variety of diseases or conditions associated with inflammation or inflammatory response, autoimmune diseases, rheumatoid arthritis, cardiovascular diseases, or abnormal cell proliferation or cancer.
• US7582785B2
  申请人：——

  公开号：US7582785B2

  公开（公告）日：2009-09-01
• US7902257B2
  申请人：——

  公开号：US7902257B2

  公开（公告）日：2011-03-08
• US8461201B2
  申请人：——

  公开号：US8461201B2

  公开（公告）日：2013-06-11