5-furan-2-yl-isoxazole-3-carboxylic acid phenethyl-amide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5-furan-2-yl-isoxazole-3-carboxylic acid phenethyl-amide
• 英文别名: 5-(2-furyl)-N-(2-phenylethyl)isoxazole-3-carboxamide；5-(furan-2-yl)-N-(2-phenylethyl)-1,2-oxazole-3-carboxamide
• 化学式: C₁₆H₁₄N₂O₃
• 分子量: 282.299
• InChiKey: KSWYOFGMLOJPMD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  68.3
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Isoxazole Derivatives and Use Thereof
  申请人：Cho Jeong Woo

  公开号：US20090131336A1

  公开（公告）日：2009-05-21

  Disclosed herein are isoxazole derivaties and uses thereof. Serving as agonists of Wnt, the isoxazole derivatives activate Wnt/β-catenin signaling and thus can be used in the treatment and prevention of diseases related to the signal transduction. Also, pharmaceutically acceptable salts of the isoxazole derivatives are disclosed.

  本文披露了异噁唑衍生物及其用途。作为Wnt的激动剂，异噁唑衍生物激活Wnt/β-连环蛋白信号传导，因此可用于治疗和预防与信号传导相关的疾病。此外，还披露了异噁唑衍生物的药用盐。
• ISOXAZOLE DERIVATIVES AND USE THEREOF
  申请人：SK Biopharmaceuticals Co., Ltd.

  公开号：EP1971600B1

  公开（公告）日：2013-08-21
• INTERFERON-INDUCING COMPOUNDS AND USES THEREOF
  申请人：Shaw Megan

  公开号：US20120308608A1

  公开（公告）日：2012-12-06

  Provided herein are Compounds that induce interferon production and methods for identifying such Compounds. Also provided herein are compositions comprising such Compounds and methods of using such Compounds to treat interferon-sensitive diseases such as viral infections, cancer, and multiple sclerosis.
• US7915297B2
  申请人：——

  公开号：US7915297B2

  公开（公告）日：2011-03-29
• [EN] ISOXAZOLE DERIVATIVES AND USE THEREOF<br/>[FR] DERIVES D'ISOXASOLE ET LEUR UTILISATION
  申请人：SK CORP

  公开号：WO2007078113A1

  公开（公告）日：2007-07-12

  [EN] Disclosed herein are isoxazole derivaties and uses thereof. Serving as agonists of Wnt, the isoxazole derivatives activate Wnt/ß-catenin signaling and thus can be used in the treatment and prevention of diseases related to the signal transduction. Also, pharmaceutically acceptable salts of the isoxazole derivatives are disclosed.
  [FR] L'invention porte sur des dérivés d'isoxasole et sur leurs utilisations. Utilisés comme agonistes de Wnt, les dérivés d'isoxasole activent la signalisation Wnt/ß-caténine et peuvent ainsi être utilisés dans le traitement et la prévention de maladies liées à la transduction de signaux. L'invention concerne également des sels pharmaceutiquement acceptables des dérivés d'isoxazole.