2-(2-Hydroxyethyl)-3,5-dioxohexanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: 2-(2-Hydroxyethyl)-3,5-dioxohexanoic acid
• 英文别名: 2-(2-hydroxyethyl)-3,5-dioxohexanoic acid
• 化学式: C₈H₁₂O₅
• 分子量: 188.18
• InChiKey: ACJSFAZTNKPTCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  91.7
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] COMPOSITIONS AND METHODS FOR TREATING KABUKI SYNDROME AND RELATED DISORDERS<br/>[FR] COMPOSITIONS ET MÉTHODES PERMETTANT DE TRAITER LE SYNDROME DE KABUKI ET LES TROUBLES ASSOCIÉS
  申请人：UNIV JOHNS HOPKINS

  公开号：WO2015184279A1

  公开（公告）日：2015-12-03

  A method is provided for treating a Mendelian disorder of the epigenetic machinery (e.g., Kabuki syndrome) in a subject in need thereof. In particular, the method comprises administering to the subject a ketogenic composition in an amount sufficient to produce a physiologically acceptable ketosis in the subject. A method for selecting a subject for treatment of a Mendelian disorder of the epigenetic machinery (e.g., Kabuki syndrome) is also provided. Ketogenic compositions and kits useful for practicing the methods are also provided.