2-(Thiophen-2-ylmethylamino)acetic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(Thiophen-2-ylmethylamino)acetic acid
• 化学式: C₇H₉NO₂S
• mdl: MFCD03450342
• 分子量: 171.22
• InChiKey: VJIBYXPWCAWSDY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.285
• 拓扑面积：
  85
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] O-GLCNAC TRANSFERASE INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE LA O-GLCNAC TRANSFÉRASE ET LEURS UTILISATIONS
  申请人：HARVARD COLLEGE

  公开号：WO2020047251A1

  公开（公告）日：2020-03-05

  Provided herein are O-GlcNAc transferase (OGT) inhibitor compounds of Formula (I'), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating and/or preventing diseases (e.g., diabetes and complications thereof, neurodegenerative diseases, proliferative diseases such as cancers, autoimmune diseases, and inflammatory diseases) in a subject. Provided are methods of inhibiting OGT in a subject or biological sample.

  本发明提供了O-葡萄糖醛酸转移酶（OGT）抑制化合物，其化学公式为（I'），以及药用可接受的盐、溶剂化物、水合物、多晶型、共晶、互变异构体、对映异构体、同位素标记衍生物、前药和由其组成的组合物。还提供了涉及本发明的化合物或组合物用于治疗和/或预防受试者疾病（例如，糖尿病及其并发症、神经退行性疾病、增殖性疾病如癌症、自身免疫病和炎症性疾病）的方法和试剂盒。还提供了在受试者或生物样本中抑制OGT的方法。
• Peptoid
  申请人：The University of Durham

  公开号：US20180201647A1

  公开（公告）日：2018-07-19

  The invention relates to peptoids, derivatives and analogues thereof, and to methods of chemically synthesising such compounds. The invention relates to mixed peptoids, derivatives and analogues thereof comprising lysine and arginine type monomers, which may be linear or cyclic, and to their uses in therapy, for example as antimicrobial agents, and in methods for treating microbial infections.
• O-GLCNAC TRANSFERASE INHIBITORS AND USES THEREOF
  申请人：President and Fellows of Harvard College

  公开号：US20210346367A1

  公开（公告）日：2021-11-11

  Provided herein are O-GlcNAc transferase (OGT) inhibitor compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating and/or preventing diseases (e.g., diabetes and complications thereof, neurodegenerative diseases, proliferative diseases such as cancers, autoimmune diseases, and inflammatory diseases) in a subject. Provided are methods of inhibiting OGT in a subject or biological sample.
• [EN] CARBOXYLIC ACID AMIDES AS FACTOR XA INHIBITORS<br/>[FR] UTILISATION D'AMIDES D'ACIDE CARBOXYLIQUE EN TANT QU'INHIBITEURS DU FACTEUR XA
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2008135526A1

  公开（公告）日：2008-11-13

  [EN] The present invention relates to new substituted carboxylic acid amides of general formula (I), wherein D, B, R³, R⁴ and R⁵ are defined as in the specification, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.
  [FR] L'invention concerne de nouveaux amides d'acide carboxylique substitués représentés par la formule (I) dans laquelle D, B, R³, R⁴ et R⁵ correspondent à leur définition dans la spécification, leurs tautomères, leurs énantiomères, leurs diastéréomères, leurs mélanges et leurs sels, en particulier, leurs sels acceptables sur le plan physiologique avec des bases ou des acides organiques ou inorganiques, ces amides possédant d'excellentes propriétés.