(2S)-2-(icosa-5,8,11,14-tetraenylamino)propanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-2-(icosa-5,8,11,14-tetraenylamino)propanoic acid
• 化学式: C₂₃H₃₉NO₂
• 分子量: 361.6
• InChiKey: ZMBYGVKXTACGHR-QFIPXVFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  26
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Lipid-amino acid conjugates and methods of use
  申请人：Burstein H. Sumner

  公开号：US20060014820A1

  公开（公告）日：2006-01-19

  N-fatty acid-amino acid conjugates and J 2 prostanoid-amino acid conjugates are disclosed along with methods for making such conjugates and methods of using these conjugates in the treatment of conditions that involve dysfunctional lipid metabolism, insulin sensitivity, glucose homeostasis, and/or inflammation.

  N-脂肪酸-氨基酸共轭物和J2前列腺素-氨基酸共轭物被披露，以及制备这些共轭物的方法和在治疗涉及异常脂质代谢、胰岛素敏感性、葡萄糖稳态和/或炎症的疾病中使用这些共轭物的方法。
• Compositions and methods for detecting and quantifying COX-2 activity by lipoamino acid metabolism
  申请人：——

  公开号：US20040029207A1

  公开（公告）日：2004-02-12

  A method of detecting an activity of a COX-2 enzyme in a subject that includes obtaining a sample of the subject; detecting an amino acid eicosanoid metabolite in the sample, wherein the presence of the amino acid eicosanoid metabolite indicates the activity of the COX-2 enzyme of the subject. Preferably the amino acid eicosanoid metabolite is a PGH 2 -Gly or HETE-Gly metabolite. The metabolite may be detected based on metabolism of a COX-2-selective substrate. Preferably, the substrate is a lipoamino acid. More preferably, the lipoamino acid is selected from NAGly, N-arachidonyl-alanine, and &dgr;-arachidonyl aminobutuyic acid.

  一种检测受试者体内 COX-2 酶活性的方法，包括获取受试者的样本；检测样本中的氨基酸类二十碳烷代谢物，其中氨基酸类二十碳烷代谢物的存在表明受试者体内 COX-2 酶的活性。氨基酸类二十烷代谢物最好是 PGH 2 -Gly 或 HETE-Gly 代谢物。代谢物可根据 COX-2 选择性底物的代谢情况进行检测。底物最好是脂氨基酸。更优选的是，脂氨基酸选自 NAGly、N-arachidonyl-alanine 和&dgr;-arachidonyl aminobutuyic acid。
• LIPID-AMINO ACID CONJUGATES AND METHODS OF USE
  申请人：University of Massachusetts

  公开号：EP1778210A2

  公开（公告）日：2007-05-02
• METHODS FOR MODULATING IKS CHANNEL ACTIVITY
  申请人：ELINDER Fredrik

  公开号：US20170216240A1

  公开（公告）日：2017-08-03

  Disclosed herein are methods of using polyunsaturated fatty acids and derivatives thereof (“PUFAs”) to modulate I ks channels to treat conditions associated with a disruption in I ks channel activity, such as cardiac arrhythmias. In particular, disclosed herein are negatively charged PUFAs having decreased pK a values, which can activate (i.e., open) I Ks channels, and positively charged PUFAs that can inhibit (i.e., close) I KS channels.
• US7314709B2
  申请人：——

  公开号：US7314709B2

  公开（公告）日：2008-01-01