6-甲氧基咪唑并[1,2-a]吡啶-3-甲醛 | 944902-87-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 中文名称: 6-甲氧基咪唑并[1,2-a]吡啶-3-甲醛
• 英文名称: 6-Methoxyimidazo[1,2-A]pyridine-3-carbaldehyde
• CAS: 944902-87-8
• 化学式: C₉H₈N₂O₂
• mdl: MFCD10698064
• 分子量: 176.175
• InChiKey: JGFCMRSKRBDNTE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.111
• 拓扑面积：
  43.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,2,3-三溴丙醛 、 2-氨基-5-甲氧基吡啶 在 溶剂黄146 作用下， 生成 6-甲氧基咪唑并[1,2-a]吡啶-3-甲醛
  参考文献：
  名称：

  2,2,3-Tribromopropanal as a Versatile Reagent in the Skraup-Type Synthesis of 3-Bromoquinolin-6-ols

  摘要：

  2,2,3-Tribromopropanal, a reagent which almost became forgotten in the chemical literature after its first application in the 1950s, is used for the one-step transformation of diversely substituted 4-nitro- and 4-methoxyanilines into 3-bromo-6-nitroquinolines and 3-bromo-6-methoxyquinolines. These intermediates are then converted, in one further step, into 3-bromoquinolin-6-ols, which may carry additional substituents at positions 7 and 8.

  DOI：

  10.1055/s-0033-1340670

文献信息

• 2,2,3-Tribromopropanal as a Versatile Reagent in the Skraup-Type Synthesis of 3-Bromoquinolin-6-ols
  作者：Clemens Lamberth、Fiona Kessabi、Renaud Beaudegnies、Laura Quaranta、Stephan Trah、Guillaume Berthon、Fredrik Cederbaum、Thomas Vettiger、CS Prasanna

  DOI：10.1055/s-0033-1340670

  日期：——

  2,2,3-Tribromopropanal, a reagent which almost became forgotten in the chemical literature after its first application in the 1950s, is used for the one-step transformation of diversely substituted 4-nitro- and 4-methoxyanilines into 3-bromo-6-nitroquinolines and 3-bromo-6-methoxyquinolines. These intermediates are then converted, in one further step, into 3-bromoquinolin-6-ols, which may carry additional substituents at positions 7 and 8.