N-<3-Phenoxy-propyl>-anilin | 25836-88-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N-<3-Phenoxy-propyl>-anilin
• 英文别名: γ-Anilino-propyl-phenyl-ether；N-(3-phenoxy-propyl)-aniline；(γ-Phenoxy-propyl)-anilin；(γ-Anilino-propyl)-phenyl-aether；N-(3-Phenoxy-propyl)-anilin；N-(3-phenoxypropyl)aniline
• CAS: 25836-88-8
• 化学式: C₁₅H₁₇NO
• mdl: MFCD13237228
• 分子量: 227.306
• InChiKey: RHEGMSOZBNWMRS-UHFFFAOYSA-N

物化性质

• 沸点：
  395.5±25.0 °C(Predicted)
• 密度：
  1.080±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-苯氧基溴丙烷 、 苯胺 生成 N-<3-Phenoxy-propyl>-anilin
  参考文献：
  名称：

  Lohmann, Chemische Berichte, 1891, vol. 24, p. 2635

  摘要：

  DOI：

文献信息

• Methods and compounds for treating depression and other disorders
  申请人：NPS PHARMACEUTICALS, INC.

  公开号：EP1790337A2

  公开（公告）日：2007-05-30

  The present invention features compounds active at both the serotonin reuptake site and the N-methyl-D-aspartate (NMDA) receptor and the use of such compounds for treating different disorders. Compounds having activity at the serotonin reuptake site and the NMDA receptor ("multi-active compounds") can be used to treat different types of disorders such as obsessive-compulsive disorders (OCD), sleep disorders, sexual dysfunction, and eating disorders.

  本发明的特点是具有在血清素再摄取位点和N-甲基-D-天门冬氨酸（NMDA）受体活性的化合物，并使用这些化合物治疗不同的疾病。具有在血清素再摄取位点和NMDA受体（“多功能化合物”）的活性的化合物可用于治疗不同类型的疾病，如强迫症障碍（OCD），睡眠障碍，性功能障碍和进食障碍。
• Copper-catalyzed Ullmann coupling under ligand- and additive- free conditions. Part 1: O-Arylation of phenols with aryl halides
  作者：Joyce Wei Wei Chang、Sheena Chee、Shiya Mak、Pongchart Buranaprasertsuk、Warinthorn Chavasiri、Philip Wai Hong Chan

  DOI：10.1016/j.tetlet.2008.01.062

  日期：2008.3

  O-Arylation of a wide variety of substituted phenols and aliphatic alcohols with aryl halides catalyzed by copper iodide under mild ligand and additive free conditions ((BU4NBr)-B-n, DMF, K3PO4, reflux, 22 h) is accomplished in good to excellent product yields (up to 95%). (c) 2008 Elsevier Ltd. All rights reserved.
• Oki,M.; Mutai,K., Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 1969, vol. 25, p. 1941 - 1951
  作者：Oki,M.、Mutai,K.

  DOI：——

  日期：——
• Lohmann, Chemische Berichte, 1891, vol. 24, p. 2635
  作者：Lohmann

  DOI：——

  日期：——
• METHODS AND COMPOUNDS FOR TREATING DEPRESSION
  申请人：NPS PHARMACEUTICALS, INC.

  公开号：EP1096926B1

  公开（公告）日：2007-02-28

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