2-(2-Prop-2-enylphenoxy)ethanamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-(2-Prop-2-enylphenoxy)ethanamine
• 化学式: C₁₁H₁₅NO
• 分子量: 177.24
• InChiKey: NWIBELKVJXFXHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] METHOD FOR PREPARING 2-ALKOXYPHENOXYETHANAMINES FROM 2-ALKOXYPHENOXYETHYLACETAMIDES<br/>[FR] PROCEDE DE PREPARATION DE 2-ALKOXYPHENOXYETHANAMINES A PARTIR DE 2-ALKOXYPHENOXYETHYLACETAMIDES
  申请人：MCM PHARMA GMBH

  公开号：WO2003095416A1

  公开（公告）日：2003-11-20

  The present invention relates to a method for preparing 2-Alkoxyphenoxyethanamines and more particularly relates to the preparation of the new chemical entity 2-Alkoxyphenoxyethylacetamides, in particular as intermediates in said method. An industrial process for the synthesis of 2-Alkoxyphenoxyethanamines which is cheap and easy to perform, is a long felt need for those skilled in the art. The object of the present invention is therefore to provide a process for the industrial production of phenoxyethanamine which is cheap and easy to perform. This object is solved by the new chemical entity 2-Alkoxyphenoxyacetamide which is prepared by reacting an ortho substituted phenol with a 2-Alkyloxazoline. By hydrolysis of the acetamide with water in the presence of organic or mineral acids such as hydrochloric acid and/or sulfuric acid, the 2-Alkylphenoxyethanamine is obtained.

  本发明涉及一种制备2-烷氧基苯氧乙胺的方法，更具体地涉及制备新化学实体2-烷氧基苯氧乙基乙酰胺，特别是作为该方法中的中间体。对于那些熟练的工艺人员来说，一种便宜且易于执行的合成2-烷氧基苯氧乙胺的工业化过程一直是迫切需要的。因此，本发明的目的是提供一种便宜且易于执行的工业生产苯氧乙胺的方法。这一目的通过新的化学实体2-烷氧基苯氧乙酰胺的制备来实现，该化合物是通过将邻位取代酚与2-烷氧噁唑啉反应制备的。通过在有机或矿物酸（如盐酸和/或硫酸）存在下用水水解乙酰胺，可以得到2-烷氧基苯氧乙胺。
• METHOD FOR PREPARING 2-ALKOXYPHENOXYETHANAMINES FROM 2-ALKOXYPHENOXYETHYLACETAMIDES
  申请人：MCM PHARMA GMBH

  公开号：EP1506156A1

  公开（公告）日：2005-02-16