4-[3-[(2-Ethoxy-2-oxoethyl)-methylamino]-3-oxopropoxy]-4-oxobut-2-enoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-[3-[(2-Ethoxy-2-oxoethyl)-methylamino]-3-oxopropoxy]-4-oxobut-2-enoic acid
• 英文别名: 4-[3-[(2-ethoxy-2-oxoethyl)-methylamino]-3-oxopropoxy]-4-oxobut-2-enoic acid
• 化学式: C₁₂H₁₇NO₇
• 分子量: 287.27
• InChiKey: HRUOIPDLLFIYNV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  20
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  110
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• PRODRUGS OF METHYL HYDROGEN FUMARATE, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USE
  申请人：Gangakhedkar Archana

  公开号：US20100048651A1

  公开（公告）日：2010-02-25

  Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions comprising prodrugs of methyl hydrogen fumarate, and methods of using prodrugs of methyl hydrogen fumarate and pharmaceutical compositions thereof for treating diseases such as psoriasis, asthma, multiple sclerosis, inflammatory bowel disease, and arthritis are disclosed.

  本发明公开了甲基氢富马酸的前药、包含甲基氢富马酸前药的药物组合物，以及利用甲基氢富马酸前药和药物组合物治疗牛皮癣、哮喘、多发性硬化、炎症性肠病和关节炎等疾病的方法。
• METHODS OF USING PRODRUGS OF METHYL HYDROGEN FUMARATE AND PHARMACEUTICAL COMPOSITIONS THEREOF
  申请人：Gangakhedkar Archana

  公开号：US20120095003A1

  公开（公告）日：2012-04-19

  Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions comprising prodrugs of methyl hydrogen fumarate, and methods of using prodrugs of methyl hydrogen fumarate and pharmaceutical compositions thereof for treating diseases such as psoriasis, asthma, multiple sclerosis, inflammatory bowel disease, and arthritis are disclosed.

  本发明涉及甲基氢富马酸的前药、包含甲基氢富马酸前药的制药组合物以及使用甲基氢富马酸前药和制药组合物治疗诸如银屑病、哮喘、多发性硬化症、炎症性肠病和关节炎等疾病的方法。
• Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions thereof, and methods of use
  申请人：XenoPort, Inc.

  公开号：EP2650279A2

  公开（公告）日：2013-10-16

  Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions comprising prodrugs of methyl hydrogen fumarate, and methods of using prodrugs of methyl hydrogen fumarate and pharmaceutical compositions thereof for treating diseases such as psoriasis, asthma, multiple sclerosis, inflammatory bowel disease, and arthritis are disclosed.

  本发明公开了富马酸甲酯原药、包含富马酸甲酯原药的药物组合物，以及使用富马酸甲酯原药及其药物组合物治疗牛皮癣、哮喘、多发性硬化症、炎症性肠病和关节炎等疾病的方法。
• Methods of treating heart failure diseases using prodrugs of methyl hydrogen fumarate
  申请人：Rajasekhar Vijaykumar

  公开号：US10463642B2

  公开（公告）日：2019-11-05

  Pharmaceutical compositions comprising prodrugs of methyl hydrogen fumarate, and methods of using prodrugs of methyl hydrogen fumarate and pharmaceutical compositions thereof for treating heart failure diseases such heart failure with preserved ejection fraction (HFPEF) alone or in combination with statins (HMG-CoA reductase inhibitors) are disclosed.

  本发明公开了包含富马酸甲酯原药的药物组合物，以及使用富马酸甲酯原药及其药物组合物治疗心力衰竭疾病（如射血分数保留型心力衰竭（HFPEF））的方法，这些方法可单独使用，也可与他汀类药物（HMG-CoA 还原酶抑制剂）联合使用。
• METHODS OF TREATING HEART FAILURE DISEASES USING PRODRUGS OF METHYL HYDROGEN FUMARATE
  申请人：Rajasekhar Vijaykumar

  公开号：US20170216242A1

  公开（公告）日：2017-08-03

  Pharmaceutical compositions comprising prodrugs of methyl hydrogen fumarate, and methods of using prodrugs of methyl hydrogen fumarate and pharmaceutical compositions thereof for treating heart failure diseases such heart failure with preserved ejection fraction (HFPEF) alone or in combination with statins (HMG-CoA reductase inhibitors) are disclosed.