(S)-4-Methyl-2-(naphthalen-1-ylamino)-pentanoic acid undec-10-enyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-4-Methyl-2-(naphthalen-1-ylamino)-pentanoic acid undec-10-enyl ester
• 英文别名: undec-10-enyl (2S)-4-methyl-2-(naphthalen-1-ylamino)pentanoate
• 化学式: C₂₇H₃₉NO₂
• 分子量: 409.612
• InChiKey: MNSNVJDWWNIROE-SANMLTNESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.3
• 重原子数：
  30
• 可旋转键数：
  16
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-Methyl-2-(naphthalen-1-ylamino)-pentanoic acid undec-10-enyl ester 在 (3,5-(NO₂)2-benzoyl-L-Leu-Abu-aminomethylated polystyrene 作用下， 以 正己烷 、 异丙醇 为溶剂， 反应 24.0h， 生成 (R)-4-Methyl-2-(naphthalen-1-ylamino)-pentanoic acid undec-10-enyl ester 、 (S)-4-Methyl-2-(naphthalen-1-ylamino)-pentanoic acid undec-10-enyl ester
  参考文献：
  名称：

  Screening of a Parallel Combinatorial Library for Selectors for Chiral Chromatography

  摘要：

  A method to screen parallel combinatorial libraries for chiral selectors is described. Crucial elements to such an approach are the efficient syntheses of potential chiral selectors on synthesis resins and the rapid screening of selectors attached to these resins with circular dichroism measurement. The method does not require any immobilization of the analyte and could complement the mixture combinatorial library method developed earlier in this laboratory. The feasibility of this parallel library screening procedure is demonstrated with a model study of the chiral HPLC resolution of (1-naphthyl)leucine ester (1) using a 16-member small library.

  DOI：

  10.1021/ac9905017