2,4-Dimethyl-1-(4-methylphenyl)pyrrole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 2,4-Dimethyl-1-(4-methylphenyl)pyrrole
• 英文别名: 2,4-dimethyl-1-(4-methylphenyl)pyrrole
• 化学式: C₁₃H₁₅N
• 分子量: 185.26
• InChiKey: BMUSNBLGMYTMTQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  4.9
• 氢给体数：
  0
• 氢受体数：
  0

文献信息

• [EN] Traf2- AND Nck-INTERACTING KINASE (TNIK) INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE KINASE INTERAGISSANT AVEC TRAF2 ET NCK (TNIK) ET LEURS UTILISATIONS
  申请人：TNIK THERAPEUTICS LTD

  公开号：WO2022034587A1

  公开（公告）日：2022-02-17

  Compounds represented by Formula (I): wherein W is a nitrogen-containing moiety attached to said X via said nitrogen atom, and all other variables are as defined in the specification, processes of preparing same and uses thereof for treating medical conditions associated with upregulated activity of TNIK are provided.

  提供由公式（I）表示的化合物：其中W是通过该氮原子连接到X的含氮基团，所有其他变量如规范中所定义，以及制备它们的过程和用于治疗与TNIK上调活性相关的医疗状况的用途。
• COMPOUNDS AND COMPOSITIONS FOR INDUCING CHONDROGENESIS
  申请人：NOVARTIS AG

  公开号：US20170239227A1

  公开（公告）日：2017-08-24

  The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds, and methods of using such compounds for treatment of joint damage or joint injury in a mammal, and for inducing differentiation of mesenchymal stem cells into chondrocytes.