Propionyl 3,4,6-Tri-O-acetyl-2-acetamido-2-deoxy--D-thiogalactopyranoside

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Propionyl 3,4,6-Tri-O-acetyl-2-acetamido-2-deoxy--D-thiogalactopyranoside
• 英文别名: 3-[3-acetamido-4,5-diacetyloxy-6-(acetyloxymethyl)oxan-2-yl]sulfanylpropanoic acid
• 化学式: C₁₇H₂₅NO₁₀S
• 分子量: 435.4
• InChiKey: WLORUKFYOHVXSC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  29
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  180
• 氢给体数：
  2
• 氢受体数：
  11

文献信息

• CLEARING AGENT
  申请人：SAVID THERAPEUTICS INC.

  公开号：US20190382435A1

  公开（公告）日：2019-12-19

  It is an object of the present invention to provide a clearing agent, by which after a fusion of the streptavidin mutant and a molecular probe has been administered, the fusion, which is not localized in a target site such as an affected site but remains in the body, can be promptly removed (cleared) from the body. The present invention provides a compound represented by the following formula (1) or a salt thereof: wherein X1a, X1b, X2a and X2b each independently represent O or NH; Y 1 and Y 2 each independently represent C or S; Z 1 and Z 2 each independently represent O, S or NH; V 1 and V 2 each independently represent S or S + —O − ; n1 and n2 each independently represent an integer of 0 or 1; L10 and L12 each independently represent a divalent linking group; L11 represents a trivalent linking group; L14 represents a divalent linking group; and Sugar represents a sugar residue.

  本发明的目的是提供一种清除剂，通过该清除剂可以迅速清除融合物，即链霉亲和素突变体和分子探针的融合物，该融合物未定位在目标部位（如患处），而是留在体内。本发明提供一种由以下式（1）或其盐所表示的化合物： 其中，X1a、X1b、X2a和X2b各自独立地表示O或NH；Y1和Y2各自独立地表示C或S；Z1和Z2各自独立地表示O、S或NH；V1和V2各自独立地表示S或S+—O−；n1和n2各自独立地表示0或1；L10和L12各自独立地表示二价连接基；L11表示三价连接基；L14表示二价连接基；Sugar表示糖残基。