Methylsulfonyl octadec-9-enoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: Methylsulfonyl octadec-9-enoate
• 英文别名: methylsulfonyl octadec-9-enoate
• 化学式: C₁₉H₃₆O₄S
• 分子量: 360.6
• InChiKey: DSFIMXARRQXIJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  24
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  68.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] REVERSE HEAD GROUP LIPIDS, LIPID PARTICLE COMPOSITIONS COMPRISING REVERSE HEADGROUP LIPIDS, AND METHODS FOR THE DELIVERY OF NUCLEIC ACIDS<br/>[FR] LIPIDES À TÊTES POLAIRES INVERSÉES, COMPOSITIONS PARTICULAIRES LIPIDIQUES COMPRENANT LES LIPIDES À TÊTES POLAIRES INVERSÉES, ET PROCÉDÉS D'ADMINISTRATION D'ACIDES NUCLÉIQUES
  申请人：UNIV BRITISH COLUMBIA

  公开号：WO2011056682A1

  公开（公告）日：2011-05-12

  The present invention related to a novel class of zwitterionic lipids that are useful in the preparation of lipid particles suitable for the delivery of encapsulated nucleic acids to cells.

  本发明涉及一种新型的带电离子脂质类物质，可用于制备适用于将封装的核酸传递至细胞的脂质粒子。
• [EN] IMPROVED AMINO LIPIDS AND METHODS FOR THE DELIVERY OF NUCLEIC ACIDS<br/>[FR] LIPIDES AMINÉS AMÉLIORÉS ET PROCÉDÉS D'ADMINISTRATION D'ACIDES NUCLÉIQUES
  申请人：TEKMIRA PHARMACEUTICALS CORP

  公开号：WO2010042877A1

  公开（公告）日：2010-04-15

  The present invention provides superior compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target proteins at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.

  本发明提供了用于将治疗剂传递给细胞的优越组合物和方法。具体来说，这些包括新型脂质和核酸-脂质颗粒，能够有效地封装核酸并有效地将封装的核酸传递给体内的细胞。本发明的组合物具有高度的效力，因此可以以相对较低的剂量有效地降低特定靶蛋白的表达。此外，本发明的组合物和方法与先前在艺术领域中已知的组合物和方法相比，毒性更低，并提供更大的治疗指数。
• [EN] IMPROVED CATIONIC LIPIDS AND METHODS FOR THE DELIVERY OF THERAPEUTIC AGENTS<br/>[FR] LIPIDES CATIONIQUES ET PROCÉDÉS AMÉLIORÉS POUR L'ADMINISTRATION D'AGENTS THÉRAPEUTIQUES
  申请人：PROTIVA BIOTHERAPEUTICS INC

  公开号：WO2011000106A1

  公开（公告）日：2011-01-06

  The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.

  本发明提供了用于将治疗剂传递到细胞的组合物和方法。具体包括新型阳离子脂质和核酸-脂质颗粒，它们能够有效地封装核酸并将封装的核酸有效地传递到体内的细胞中。本发明的组合物具有很高的效力，因此可以在相对较低的剂量下有效地降低特定靶蛋白的表达。此外，本发明的组合物和方法与先前已知的组合物和方法相比，毒性较低，提供更高的治疗指数。
• [EN] AGENTS FOR IMPROVED DELIVERY OF NUCLEIC ACIDS TO EUKARYOTIC CELLS<br/>[FR] AGENTS PERMETTANT D'AMÉLIORER L'ADMINISTRATION D'ACIDES NUCLÉIQUES DANS DES CELLULES EUCARYOTES
  申请人：MOLECULAR TRANSFER INC

  公开号：WO2013158127A1

  公开（公告）日：2013-10-24

  New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes.

  提供了新的阳离子脂质，可用于将大分子（如核酸）传递到真核细胞中。这些脂质可以单独使用，与其他脂质和/或其他转染增强试剂结合使用，以制备转染复合物。
• [EN] AGENTS FOR IMPROVED DELIVERY OF NUCLEIC ACIDS TO EUKARYOTIC CELLS<br/>[FR] AGENTS POUR UNE ADMINISTRATION AMÉLIORÉE D'ACIDES NUCLÉIQUES À DES CELLULES EUCARYOTES
  申请人：MOLECULAR TRANSFER INC

  公开号：WO2012142622A1

  公开（公告）日：2012-10-18

  New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes.

  提供了新的阳离子脂质，可用于将大分子（如核酸）传递到真核细胞中。这些脂质可以单独使用，与其他脂质和/或其他转染增强试剂结合使用，制备转染复合物。