4-(Dimethylamino)-2,2,4-trimethylpentanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-(Dimethylamino)-2,2,4-trimethylpentanoic acid
• 英文别名: 4-(dimethylamino)-2,2,4-trimethylpentanoic acid
• 化学式: C₁₀H₂₁NO₂
• 分子量: 187.28
• InChiKey: QAGOTQMFALOFDN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] CATIONIC LIPIDS FOR NUCLEIC ACID DELIVERY AND PREPARATION THEREOF<br/>[FR] LIPIDES CATIONIQUES POUR L'ADMINISTRATION D'ACIDES NUCLÉIQUES ET LEUR PRÉPARATION
  申请人：TECH INNOVATION MOMENTUM FUND ISRAEL LIMITED PARTNERSHIP

  公开号：WO2018087753A1

  公开（公告）日：2018-05-17

  The present invention provides cationic lipids and lipid nanoparticle formulations comprising these lipids, alone or in combination with other lipids. These lipid nanoparticles may be formulated with nucleic acids to facilitate their intracellular delivery both in vitro and for therapeutic applications. The present invention also provides methods of chemical synthesis of these lipids, lipid nanoparticle preparation and formulation with nucleic acids.

  本发明提供了阳离子脂质和脂质纳米粒子配方，包括这些脂质单独使用或与其他脂质结合。这些脂质纳米颗粒可以与核酸配方，以促进它们在体外和治疗应用中的细胞内传递。本发明还提供了这些脂质的化学合成方法，脂质纳米颗粒制备和与核酸配方的配方方法。
• CATIONIC LIPIDS
  申请人：Takeda Pharmaceutical Company Limited

  公开号：US20200331841A1

  公开（公告）日：2020-10-22

  The present invention provides a technique that enables introduction of active ingredients, in particular, nucleic acids, into cells with superior efficiency; and cationic lipids, etc., for use in the technique. The compound or a salt thereof according to the present invention is a compound represented by formula (I) or a salt thereof. In formula (I), n represents an integer of 2 to 5, R represents a linear C 1-5 alkyl group, a linear C 7-11 alkenyl group, or a linear C 11 alkadienyl group, and wavy lines each independently represent a cis-bond or a trans-bond.

  本发明提供了一种技术，能够以优越的效率将活性成分，特别是核酸，引入细胞中；以及用于该技术的阳离子脂质等。根据本发明的化合物或其盐是由式（I）表示的化合物或其盐。在式（I）中，n代表2到5的整数，R代表线性C1-5烷基基团、线性C7-11烯基基团或线性C11烯二烯基团，波浪线各自独立表示顺式键或反式键。