4-Chlor-1-(4-biphenyloxy)-2-butanol | 59747-98-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Chlor-1-(4-biphenyloxy)-2-butanol
• 英文别名: 4-Chloro-(4-biphenylyloxy)-2-butanol；4-chloro-1-(4-phenylphenoxy)butan-2-ol
• CAS: 59747-98-7
• 化学式: C₁₆H₁₇ClO₂
• 分子量: 276.763
• InChiKey: DZAWKDGFUDCKLY-UHFFFAOYSA-N

物化性质

• 熔点：
  123-124 °C(Solv: isopropanol (67-63-0))
• 沸点：
  462.5±40.0 °C(Predicted)
• 密度：
  1.165±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-Chlor-1-(4-biphenyloxy)-2-butanol 在 sodium carbonate 作用下， 以 正丁醇 为溶剂， 以3.7 g (62%)的产率得到1-(4-Phenyl-phenoxy)-4-(4-phenyl-1-piperazinyl)-2-butanol
  参考文献：
  名称：

  1-aryloxy-4-[((4-aryl)-1-piperazinyl]-2-butanols useful as antiallergy

  摘要：

  公式为1-芳氧基-4-[(4-芳基)-1-哌嗪基]-2-丁醇，其中Ar从##STR2##或2、3或4-吡啶基中选择；X和X'从氢、较低烷基、较低烷氧基、卤素、三氟甲基、硝基、乙酰氨基、苯基或##STR3##乙酰基、氰基、氨基甲酰基、羧基或较低烷基羧酸酯中选择；Y、Y'、Y"从与X和X'相同的组中选择，但排除苯基和取代苯基；Z和Z'从氢、较低烷基或较低烷氧基中选择，其药用盐用于抑制或对抗动物和人体中与过敏性反应相关的过敏性敏感性。

  公开号：

  US04882330A1
• 作为产物：
  描述：

  1,4-二氯-2-丁醇 生成 4-Chlor-1-(4-biphenyloxy)-2-butanol
  参考文献：
  名称：

  WALSH, DAVID A.;YANNI, JOHN M.

  摘要：

  DOI：

文献信息

• 1-Aryloxy-4-amino-2-butanols
  申请人：A. H. Robins Company, Inc.

  公开号：US04463190A1

  公开（公告）日：1984-07-31

  Novel 1-aryloxy-4-amino-2-butanols of the formula ArO--CH.sub.2 --CHOH--CH.sub.2 --CH.sub.2 --NR.sup.1 R.sup.2 wherein Ar is 1-naphthyl, 2-naphthyl, indene-4(or 5-)yl, 3-(or 5-)chloro-2-pyridyl, phenyl, monosubstituted phenyl or di-substituted phenyl, R.sup.1 is lower alkyl, phenyl, phenylalkyl, 2-hydroxymethyl-2-propyl, adamantyl or lower-cycloalkyl, R.sup.2 is hydrogen or lower alkyl, wherein R.sup.1 and R.sup.2 together with the adjacent nitrogen form a heterocyclic residue and the pharmaceutically acceptable acid addition salts thereof having local anesthetic, beta-adrenergic blocking, antihypertensive and antiarrhythmic properties are disclosed. The compounds are prepared by reacting novel 1-aryloxy-4-chloro-2-butanols with amines. Methods for the preparation of the novel 1-aryloxy-4-chloro-2-butanol intermediates are also disclosed.

  公开了一种化合物及其药物学上可接受的酸加成盐，其化学式为ArO-CH2-CHOH-CH2-CH2-NR1R2，其中Ar为1-萘基，2-萘基，4-或5-吲哚基，3-或5-氯-2-吡啶基，苯基，单取代苯基或双取代苯基，R1为较低烷基，苯基，苯基烷基，2-羟甲基-2-丙基，金刚烷基或较低环烷基，R2为氢或较低烷基，其中R1和R2与相邻的氮一起形成杂环残基，具有局部麻醉，β-肾上腺素受体阻滞，降压和抗心律失常作用。该化合物通过将新型1-芳氧基-4-氯-2-丁醇与胺反应制备而成。还公开了制备新型1-芳氧基-4-氯-2-丁醇中间体的方法。
• 1-aryloxy-4-amino-2-butanols
  申请人：A. H. Robins Company, Incorporated

  公开号：US04806555A1

  公开（公告）日：1989-02-21

  Novel 1-aryloxy-4-amino-2-butanols of the formula ArO--CH.sub.2 --CHOH--CH.sub.2 --CH.sub.2 --NR.sup.1 R.sup.2 wherein Ar is 1-naphthyl, 2-naphthyl, indene-4(or 5-)yl, 3-(or 5-)chloro-2-pyridyl, phenyl, monosubstituted phenyl or di-substituted phenyl, R.sup.1 is lower alkyl, phenyl, phenylalkyl, 2-hydroxymethyl-2-propyl, adamantyl or lower-cycloalkyl, R.sup.2 is hydrogen or lower alkyl, wherein R.sup.1 and R.sup.2 together with the adjacent nitrogen from a heterocyclic residue and the pharmaceutically acceptable acid addition salts thereof having local anesthetic, beta-adrenergic blocking, antihypertensive and antiarrhythmic properties are disclosed. The compounds are prepared by reacting novel 1-aryloxy-4-chloro-2-butanols with amines. Methods for the preparation of the novel 1-aryloxy-4-chloro-2-butanol intermediates are also disclosed.

  化合物的名称为Novel 1-aryloxy-4-amino-2-butanols，化学式为ArO--CH.sub.2 --CHOH--CH.sub.2 --CH.sub.2 --NR.sup.1 R.sup.2，其中Ar可以是1-萘基、2-萘基、茚-4（或5-）基、3-（或5-）氯基-2-吡啶基、苯基、单取代苯基或二取代苯基，R.sup.1可以是较低的烷基、苯基、苯基烷基、2-羟甲基-2-丙基、金刚烷基或较低的环烷基，R.sup.2可以是氢或较低的烷基。这些化合物与相邻氮原子组成杂环残基，并且它们的药物可接受的酸盐具有局部麻醉、β-肾上腺素受体阻滞、降压和抗心律失常的性质。这些化合物是通过将新型的1-芳氧基-4-氯-2-丁醇与胺反应制备而成的。此外，还公开了制备新型1-芳氧基-4-氯-2-丁醇中间体的方法。
• Certain aryloxy-4-chloro-2-butanol intermediates
  申请人：A. H. Robins Company, Inc.

  公开号：US04609735A1

  公开（公告）日：1986-09-02

  Novel 1-aryloxy-4-amino-2-butanols of the formula ArO--CH.sub.2 --CHOH--CH.sub.2 --CH.sub.2 --NR.sup.1 R.sup.2 wherein AR is 1-naphythyl, 2-naphthyl, indene-4(or 5-)yl, 3-(or 5-)chloro-2-pyridyl, phenyl, monosubstituted phenyl or di-substituted phenyl, R.sup.1 is lower alkyl, phenyl, phenylalkyl, 2-hydroxymethyl-2-propyl, adamantyl or lower-cycloalkyl, R.sup.2 is hydrogen or lower alkyl, wherein R.sup.1 and R.sup.2 together with the adjacent nitrogen form a heterocyclic residue and the pharmaceutically acceptable acid addition salts thereof having local anesthetic, beta-adrenergic blocking, antihypertensive and antiarrhythmic properties are disclosed. The compounds are prepared by reacting novel 1-aryloxy-4-chloro-2-butanols with amines. Methods for the preparation of the novel 1-aryloxy-4-chloro-2-butanol intermediates are also disclosed.

  公开了化学式为ArO--CH.sub.2 --CHOH--CH.sub.2 --CH.sub.2 --NR.sup.1 R.sup.2的新型1-芳氧基-4-氨基-2-丁醇，其中AR是1-萘基、2-萘基、茚-4（或5-）基、3-（或5-）氯-2-吡啶基、苯基、单取代苯基或双取代苯基，R.sup.1是较低的烷基、苯基、苯基烷基、2-羟甲基-2-丙基、金刚烷基或较低的环烷基，R.sup.2是氢或较低的烷基，其中R.sup.1和R.sup.2与相邻的氮一起形成杂环残基，其药物可接受的酸盐具有局部麻醉、β-肾上腺素受体阻滞、降压和抗心律失常的性质。该化合物是通过将新型的1-芳氧基-4-氯-2-丁醇与胺反应制备而成。公开了制备新型1-芳氧基-4-氯-2-丁醇中间体的方法。
• 1-Aryloxy-4-amino-2-butanols and the pharmaceutical use thereof
  申请人：A. H. Robins Company, Inc.

  公开号：US04379167A1

  公开（公告）日：1983-04-05

  Novel 1-aryloxy-4-amino-2-butanols of the formula ArO--CH.sub.2 --CHOH--CH.sub.2 --CH.sub.2 --NR.sup.1 R.sup.2 wherein Ar is 1-naphthyl, 2-naphthyl, indene-4(or 5-)yl, 3-(or 5-)chloro-2-pyridyl, phenyl, monosubstituted phenyl or di-substituted phenyl, R.sup.1 is lower alkyl, phenyl, phenylalkyl, 2-hydroxymethyl-2-propyl, adamantyl or lower-cycloalkyl, R.sup.2 is hydrogen or lower alkyl, wherein R.sup.1 and R.sup.2 together with the adjacent nitrogen form a heterocyclic residue and the pharmaceutically acceptable acid addition salts thereof having local anesthetic, beta-adrenergic blocking, antihypertensive and antiarrhythmic properties are disclosed. The compounds are prepared by reacting novel 1-aryloxy-4-chloro-2-butanols with amines. Methods for the preparation of the novel 1-aryloxy-4-chloro-2-butanol intermediates are also disclosed.

  公开了一种新型的化合物及其药物可接受的酸盐，其化学式为ArO-CH2-CHOH-CH2-CH2-NR1R2，其中Ar为1-萘基，2-萘基，吲哚-4（或5-）基，3-（或5-）氯-2-吡啶基，苯基，单取代苯基或双取代苯基，R1为低碳基，苯基，苯基烷基，2-羟甲基-2-丙基，金刚烷基或低环烷基，R2为氢或低碳基，其中R1和R2与相邻的氮一起形成杂环残基。该化合物具有局部麻醉，β-肾上腺素阻滞，降压和抗心律失常性质。该化合物是通过将新型的1-芳氧基-4-氯-2-丁醇与胺反应制备而成。还公开了制备新型1-芳氧基-4-氯-2-丁醇中间体的方法。
• 1-Aryloxy-4-[(4-aryl)-1-piperazinyl]-2-butanols useful as antiallergy agents
  申请人：A.H. ROBINS COMPANY, INCORPORATED

  公开号：EP0269383A2

  公开（公告）日：1988-06-01

  1-Aryloxy-4-[(4-aryl)-1-piperazinyl]-2-butanols of the formula: wherein Ar is selected from or 2, 3 or 4-pyridyl); X and Xʹ are selected from the group of hydrogen, loweralkyl, loweralkoxy, halogen, tri­fluoromethyl, nitro, acetylamino, phenyl or acetyl, cyano, aminocarbonyl, carboxy, or loweralkyl carboxylic acid ester; Y, Yʹ, Yʺ and Xʺ are selected from the same group as X and Xʹ except phenyl and substituted phenyl are excluded; Z and Zʹ are selected from hydrogen, loweralkyl or loweralkoxy and the pharmaceutically acceptable salt thereof are useful in inhibiting or combatting allergic response associated with anaphylactic sensitivity in animals and humans.

  式中的 1-芳氧基-4-[(4-芳基)-1-哌嗪基]-2-丁醇： 其中 Ar 选自 或 2、3 或 4-吡啶基）； X 和 Xʹ 选自氢、低级烷基、低级烷氧基、卤素、三氟甲基、硝基、乙酰氨基、苯基或 Y、Yʹ、Yʺ和 Xʺ选自与 X 和 Xʹ相同的组，但不包括苯基和取代苯基；Z 和 Zʹ选自氢、低级烷基或低级烷氧基及其药学上可接受的盐，可用于抑制或对抗动物和人类与过敏反应相关的过敏反应。