The present invention relates to broad spectrum β-lactamase inhibitors. More particularly, the invention relates to inhibitors of Class B metallo (MBL) and Class D (OXA) β-lactamases. A method of treating a bacterial infection is provided, wherein the method comprises administering to a mammalian patient in need of such treatment a compound of formula (I)
wherein
R
1
is selected from
R
2
is selected from
with certain provisos as herein defined;
in combination with a pharmaceutically acceptable β-lactam antibiotic in an amount which is effective for treating the bacterial infection.
本发明涉及广谱β-内酰胺酶抑制剂。更具体地,本发明涉及类B
金属酶(MBL)和类D(OXA)β-内酰胺酶的
抑制剂。提供了一种治疗细菌感染的方法,其中该方法包括向需要此类治疗的哺乳动物患者施用式(I)的化合物,其中R1选自,R2选自,具有如此定义的某些条件;与一种药学上可接受的β-内酰胺类抗生素结合使用,其用量有效用于治疗细菌感染。