2-Brom-4-chlor-2,4-dimethylpentan | 54191-86-5

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氯化物
• 英文名称: 2-Brom-4-chlor-2,4-dimethylpentan
• 英文别名: 2-bromo-4-chloro-2,4-dimethyl-pentane；2-Bromo-4-chloro-2,4-dimethylpentane；2-bromo-4-chloro-2,4-dimethylpentane
• CAS: 54191-86-5
• 化学式: C₇H₁₄BrCl
• 分子量: 213.545
• InChiKey: HRQQPFOHNBBFMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  2,4-二甲基-3-戊醇 在 吡啶 、 氯化亚砜 、 氢溴酸 作用下， 以 二氯甲烷 为溶剂， 生成 2-Brom-4-chlor-2,4-dimethylpentan
  参考文献：
  名称：

  Block and graft copolymers by selective cationic initiation. I. Selective alkylation with trialkylaluminums on the chlorine of chlorobrominated alkanes

  摘要：

  DOI：

  10.1021/jo00896a023

文献信息

• SIGMA RECEPTOR INHIBITORS
  申请人：Cuberes-Altisent Rosa

  公开号：US20090247525A1

  公开（公告）日：2009-10-01

  The invention relates to compounds of formula I having pharmacological activity towards the sigma receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which the sigma receptor is involved.

  本发明涉及具有对sigma受体药理活性的化合物的公式I，以及制备这些化合物的过程，包括它们的制药组合物，以及它们用于治疗和/或预防sigma受体参与的疾病的用途。
• C5aR ANTAGONISTS
  申请人：Fan Pingchen

  公开号：US20110275639A1

  公开（公告）日：2011-11-10

  Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.

  提供了一些调节C5a受体的化合物。这些化合物是取代的哌啶，并且在制药组合物、治疗涉及C5a受体病理激活的疾病和障碍的方法中有用。
• PYRAZOLE DERIVATIVES AS SIGMA RECEPTOR INHIBITORS
  申请人：CUBERES-ALTISENT Rosa

  公开号：US20120232093A1

  公开（公告）日：2012-09-13

  The invention relates to compounds of formula I having pharmacological activity towards the sigma receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which the sigma receptor is involved.

  本发明涉及一种具有对sigma受体的药理活性的化合物，以及制备这些化合物的过程，包括含有它们的制药组合物，以及它们用于治疗和/或预防与sigma受体有关的疾病的用途。
• IMIDAZOLE COMPOUNDS HAVING PHARMACEUTICAL ACTIVITY TOWARDS THE SIGMA RECEPTOR
  申请人：Cuberes-Altisent Rosa

  公开号：US20090137560A1

  公开（公告）日：2009-05-28

  The present invention relates to compounds of formula (I), methods for their preparation, medicaments comprising these compounds as well their use in the manufacture of a medicament for the treatment of humans and animals.

  本发明涉及公式（I）的化合物，其制备方法，包括这些化合物的药物以及它们在制造用于治疗人类和动物的药物中的使用。
• Dual function drugs and uses thereof
  申请人：Altar A. Charles

  公开号：US20070142399A1

  公开（公告）日：2007-06-21

  Dual action compounds are provided that are inhibitors of catechol-omethyltransferase (COMT) enzyme and are also partial agonists or antagonists of the D2 receptor, or agonists of the D1 receptor, or interact in these ways with both D1 and D2 receptors. Use of the compounds for treating neuropsychiatric disorders, particularly schizophrenia and mild cognitive impairment, is also described.