3-(2-chlorophenyl)morpholine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 3-(2-chlorophenyl)morpholine
• 化学式: C₁₀H₁₂ClNO
• mdl: MFCD09901533
• 分子量: 197.664
• InChiKey: PNOWMAVKTXSVRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] SUBSTITUTED MORPHOLINE DERIVATIVES AS ROR GAMMA MODULATORS<br/>[FR] DÉRIVÉS DE MORPHOLINE SUBSTITUÉS EN TANT QUE MODULATEURS DE ROR GAMMA
  申请人：GLENMARK PHARMACEUTICALS SA

  公开号：WO2018116285A1

  公开（公告）日：2018-06-28

  The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, R1, R2, R3, X1, X2, m and n are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORyt). These compounds prevent, inhibit, or suppress the action of RORyt and are therefore useful in the treatment of RORyt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer. (I)

  本公开涉及具有式(I)的化合物及其药学上可接受的盐，其中环A、R1、R2、R3、X1、X2、m和n如本文所定义，这些化合物作为视黄酸相关孤儿受体γt（RORγt）的调节剂具有活性。这些化合物可以预防、抑制或抑制RORγt的作用，因此在治疗RORγt介导的疾病、疾病、综合征或症状方面具有用处，例如疼痛、炎症、慢性阻塞性肺病、哮喘、类风湿关节炎、结肠炎、多发性硬化症、牛皮癣、神经退行性疾病和癌症。 (I)
• NOVEL PRMT5 INHIBITORS
  申请人：AMGEN INC.

  公开号：US20220194955A1

  公开（公告）日：2022-06-23

  Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders. Compounds of Formula I have the following structure: