6-羟基-6-氧代正亮氨酰胺 | 90485-83-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 6-羟基-6-氧代正亮氨酰胺
• 中文别名: 2,2-二[[3-(辛基硫代)-1-羰基丙氧基]甲基]丙烷-1,3-二基二[3-(辛基硫代)丙酸盐]
• 英文名称: 6-Hydroxy-6-oxonorleucinamide
• 英文别名: 5,6-diamino-6-oxohexanoic acid
• CAS: 90485-83-9
• 化学式: C₆H₁₂N₂O₃
• 分子量: 160.17
• InChiKey: ONWORFCWNLEBMF-UHFFFAOYSA-N

物化性质

• 沸点：
  414.5±40.0 °C(Predicted)
• 密度：
  1.260±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -3.8
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  106
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Charged compounds comprising a nucleic acid binding moiety and uses therefor
  申请人：——

  公开号：US20020065227A1

  公开（公告）日：2002-05-30

  Charged compounds are provided that comprise one or more regions of localized positive charge, compositions comprising such compounds, methods of synthesizing such compounds, methods of screening such compounds to identify those having anti-infective activity, and methods of using such compounds to prevent or inhibit infections. These compounds, and compositions containing them, have multiple applications, including use in human and animal medicine and in agriculture.

  提供了带有一个或多个局部正电荷区域的带电化合物，包括这些化合物的组成物，合成这些化合物的方法，筛选这些化合物以识别具有抗感染活性的化合物的方法，以及使用这些化合物预防或抑制感染的方法。这些化合物及包含它们的组成物具有多种应用，包括在人类和动物医学以及农业中的应用。
• ARYL UREA DERIVATIVES AS N-FORMYL PEPTIDE RECEPTORS LIKE-1 (FPRL-1) RECEPTOR MODULATORS
  申请人：Allergan, Inc.

  公开号：US20130123496A1

  公开（公告）日：2013-05-16

  The present invention relates to novel aryl urea derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide receptor like-1 (FPRL-1) receptor.

  本发明涉及新型芳基脲衍生物，制备它们的方法，含有它们的药物组合物以及它们作为药物的用途，作为N-甲酰肽受体类似物-1（FPRL-1）受体的调节剂。
• Amide derivatives of N-urea substituted amino acids as formyl peptide receptor like-1 (FPRL-1) receptor modulators
  申请人：Allergan, Inc.

  公开号：US10172832B2

  公开（公告）日：2019-01-08

  The present invention relates to novel amide derivatives of N-urea substituted amino acids, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide receptor like-1 (FPRL-1) receptor.

  本发明涉及 N-脲取代氨基酸的新型酰胺衍生物、其制备工艺、含有它们的药物组合物以及它们作为 N-甲酰肽受体样-1（FPRL-1）受体调节剂的药物用途。
• CHARGED COMPOUNDS COMPRISING A NUCLEIC ACID BINDING MOIETY AND USES THEREFOR
  申请人：Genesoft, Inc.

  公开号：EP1265921A1

  公开（公告）日：2002-12-18
• AMIDE DERIVATIVES OF N-UREA SUBSTITUTED AMINO ACIDS AS FORMYL PEPTIDE RECEPTOR LIKE-1 (FPRL-1) RECEPTOR MODULATORS
  申请人：Allergan, Inc.

  公开号：US20190343804A1

  公开（公告）日：2019-11-14

  The present invention relates to novel amide derivatives of N-urea substituted amino acids, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide receptor like-1 (FPRL-1) receptor.