1,3-Difluoro-2-(2-methylpropoxy)benzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1,3-Difluoro-2-(2-methylpropoxy)benzene
• 英文别名: 1,3-difluoro-2-(2-methylpropoxy)benzene
• 化学式: C₁₀H₁₂F₂O
• 分子量: 186.2
• InChiKey: YRRDXVWXJPZQAX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• NOVEL DERIVATIVES AND THEIR USE AS SELECTIVE INHIBITORS OF CASPASE-2
  申请人：Institut National de la Santé et de la Recherche Médicale (INSERM)

  公开号：EP3433243B1

  公开（公告）日：2021-09-08
• [EN] NOVEL DERIVATIVES AND THEIR USE AS SELECTIVE INHIBITORS OF CASPASE-2<br/>[FR] NOUVEAUX DÉRIVÉS ET LEUR UTILISATION COMME INHIBITEURS SÉLECTIFS DE LA CASPASE-2
  申请人：INST NAT DE LA SANTE ET DE LA RECH MEDICALE (INSERM)

  公开号：WO2017162674A1

  公开（公告）日：2017-09-28

  The present invention relates to a compound of formula (I) wherein P1, P3, P4 and P5 are amino acid residues. The invention also relates to a compound of formula (I) for its use as a Caspase-2 inhibitor and for its therapeutical use. It also concerns the use of a compound of formula (I) as activity base probe to selectively detect Caspase-2 activity.
• [EN] NOVEL COMPOUNDS AND THEIR USE AS SELECTIVE INHIBITORS OF CASPASE-2<br/>[FR] NOUVEAUX COMPOSÉS ET LEUR UTILISATION EN TANT QU'INHIBITEURS SÉLECTIFS DE CASPASE-2
  申请人：CENTRE NAT RECH SCIENT

  公开号：WO2019068538A1

  公开（公告）日：2019-04-11

  The present invention relates to a compound of formula (I), wherein P1, P3, P4 and P5 are amino acid residues or amino acid like structures. The invention also relates to a compound of formula (I) for its use as a Caspase-2 inhibitor and for its therapeutical use. It also concerns the use of a compound of formula (I) as activity base probe to selectively detect Caspase-2 activity.