N-prop-2-enylnonanamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-prop-2-enylnonanamide
• 化学式: C₁₂H₂₃NO
• 分子量: 197.32
• InChiKey: CAXZCFQSMKMBNV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  14
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Beta-aminoethyl-substituted phenyl compounds, and anti-inflammatory or analgesic compositions containing them
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0282127A2

  公开（公告）日：1988-09-14

  The present invention relates to beta-aminoethyl-substituted phenyl compounds, especially beta-aminoethoxy-substituted phenyl compounds, having the general structure: wherein: the W-X moiety is selected from -C(O)NH-, -C(S)NH-, -S(O)₂NH-, -NHC(O)O-, -NHC(S)O-, -NHC(O)NH-, and -NHC(S)NH- wherein either available bond of the W-X moiety is bonded to the R moiety and the remaining bond is attached to the benzyl carbon atom; Z is selected from hydrogen, hydroxy, and methoxy; R¹ is selected from hydrogen, hydroxy, alkyl esters of hydroxy having from about 1 to about 5 carbon atoms, alkyl having from about 1 to about 5 carbon atoms, and alkoxy having from about 1 to about 5 carbon atoms; each R² is inde­pendently selected from hydrogen, halogen, unsubstituted or substituted alkyl having from about 1 to about 5 carbon atoms, substituted or unsubstituted aryl, and carboxylate, or two R² moieties are covalently bonded to form a substituted or unsub­stituted alkyl ring having from about 3 to about 7 carbon atoms in the ring; R is a C₆-C₂₄ alkyl moiety; and Y is selected from -O-, -S- and -NH-. The present invention also relates to pharmaceutical compo­sitions comprising a safe and effective amount of a compound of the present invention and a pharmaceutically-acceptable carrier. The present invention further relates to methods for producing analgesia and reducing inflammation, in humans and lower ani­mals, by administering the compounds or compositions of the present invention. In addition, the present invention relates to methods for making compounds of the present invention and intermediates useful in these synthesis methods.

  本发明涉及具有一般结构的β-氨基乙基取代苯基化合物，特别是β-氨基乙氧基取代苯基化合物： 其中W-X分子选自-C(O)NH-、-C(S)NH-、-S(O)₂NH-、-NHC(O)O-、-NHC(S)O-、-NHC(O)NH-和-NHC(S)NH-，其中W-X分子的任一可用键与R分子键合，其余键与苄基碳原子相连；Z 选自氢、羟基和甲氧基； R¹ 选自氢、羟基、约 1 至约 5 个碳原子的羟基烷基酯、约 1 至约 5 个碳原子的烷基和约 1 至约 5 个碳原子的烷氧基；每个 R² 独立地选自氢、卤素、具有约 1 至约 5 个碳原子的未取代或取代的烷基、取代或未取代的芳基和羧基，或两个 R² 分子共价键合以形成环中具有约 3 至约 7 个碳原子的取代或未取代的烷基环；R 是 C₆-C₂₄ 烷基；以及 Y 选自-O-、-S- 和-NH-。 本发明还涉及药物组合物，其包含安全有效量的本发明化合物和药学上可接受的载体。本发明进一步涉及通过施用本发明化合物或组合物，在人类和低等动物中产生镇痛和减轻炎症的方法。此外，本发明还涉及制造本发明化合物的方法以及在这些合成方法中有用的中间体。
• The use of vanilloids for the treatment of respiratory diseases or disorders
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0401903A2

  公开（公告）日：1990-12-12

  The present invention provides methods of treating respira­tory diseases or disorders in humans and lower animals by treat­ment with natural and synthetic vanilloid compounds, and the pharmaceutically-acceptable salts thereof. This invention further relates to pharmaceutical compositions containing said natural and synthetic vanilloid compounds useful to treat the respiratory symptoms associated with respiratory diseases or disorders.

  本发明提供了通过使用天然和合成类香兰素化合物及其药学上可接受的盐类治疗人类和低等动物呼吸系统疾病或紊乱的方法。 本发明还涉及含有上述天然和合成类香草酮化合物的药物组合物，用于治疗与呼吸系统疾病或紊乱有关的呼吸道症状。
• [EN] COMPOSITION FOR THE SIMULTANEOUS DISINFECTION AND DECONTAMINATION OF BODIES CONTAMINATED BY CONVENTIONAL TRANSMISSIBLE AGENTS (CTAS) AND NON-CONVENTIONAL TRANSMISSIBLE AGENTS (NCTAS)<br/>[FR] COMPOSITION POUR LA DÉSINFECTION ET LA DÉCONTAMINATION SIMULTANÉES DE CORPS CONTAMINÉS PAR DES AGENTS TRANSMISSIBLES CONVENTIONNELS (ATC) ET NON CONVENTIONNELS (ATNC)
  申请人：ANIOS LAB SARL

  公开号：WO2009147328A2

  公开（公告）日：2009-12-10

  L'invention concerne l'utilisation d'une composition pour la désinfection et la décontamination simultanées d'objets contaminés par des agents transmissibles conventionnels (ATC), tels que notamment bactérie, levure, virus, spore de moisissure, tnycobactérie, spore de bactérie, et des agents transmissibles non conventionnels (ATNC), tels que des prions. Selon l'invention, la composition comprend une solution aqueuse de cuivre ou un de ses dérivés tel que sels de cuivre en présence d'agents oxydants de type peracide, en particulier acide peracétique. Cette composition trouvera une application particulière dans un dispositif laveur désinfecteur et peut être avantageusement obtenue à partir du mélange d'une solution d'acide peracétique et d'une solution aqueuse de cuivre, après forte dilution, permettant notamment de réduire la fréquence de remplacement des consommables, en particulier solution d'acide peracétique et solution de sels de cuivre. L'invention concernera également l'utilisation de la composition dans un dispositif laveur désinfecteur.