6-[5-[(4S)-4-aminopentyl]-2-fluoro-3-(trifluoromethoxy)phenyl]-3-[4-[(1R)-1-(3-aminopropylamino)ethyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 6-[5-[(4S)-4-aminopentyl]-2-fluoro-3-(trifluoromethoxy)phenyl]-3-[4-[(1R)-1-(3-aminopropylamino)ethyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-2-one
• 化学式: C₂₉H₃₄F₄N₆O₂
• 分子量: 574.6
• InChiKey: PCCLWTQTPHGHRC-ZWKOTPCHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  41
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  118
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• Antimicrobial Compounds and Methods of Making and Using the Same
  申请人：MELINTA THERAPEUTICS, INC.

  公开号：US20160214988A1

  公开（公告）日：2016-07-28

  The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, reducing the risk of, and delaying the onset of microbial infections in humans and animals.

  本发明通常涉及抗微生物化合物领域以及制造和使用它们的方法。这些化合物对于治疗、预防、降低人类和动物微生物感染的风险以及延迟其发病都是有用的。
• Antimicrobial compounds and methods of making and using the same
  申请人：BIOVERSYS AG

  公开号：US10815238B2

  公开（公告）日：2020-10-27

  The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, reducing the risk of, and delaying the onset of microbial infections in humans and animals.

  本发明总体上涉及抗微生物化合物领域及其制造和使用方法。这些化合物可用于治疗、预防、降低微生物感染的风险并延缓人类和动物微生物感染的发生。
• Antimicrobial Compounds And Methods Of Making And Using The Same
  申请人：Melinta Therapeutics, Inc.

  公开号：US20180065966A1

  公开（公告）日：2018-03-08

  The present disclosure relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, reducing the risk of, and delaying the onset of microbial infections in humans and animals.
• ANTIMICROBIAL COMPOUNDS AND METHODS OF MAKING AND USING THE SAME
  申请人：Melinta Therapeutics, Inc.

  公开号：US20190284190A1

  公开（公告）日：2019-09-19

  The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, reducing the risk of, and delaying the onset of microbial infections in humans and animals.