6-羧基-4,5-二氯-2,7-二甲氧基荧光素琥珀酰亚胺酯 | 113394-23-3

• 物质功能分类: 生物化工 - 生化试剂 - 荧光成像
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 中文名称: 6-羧基-4,5-二氯-2,7-二甲氧基荧光素琥珀酰亚胺酯
• 英文名称: 6-Joe SE
• 英文别名: (2,5-dioxopyrrolidin-1-yl) 4',5'-dichloro-3',6'-dihydroxy-2',7'-dimethoxy-1-oxospiro[2-benzofuran-3,9'-xanthene]-5-carboxylate
• CAS: 113394-23-3
• 化学式: C₂₇H₁₇Cl₂NO₁₁
• 分子量: 602.3
• InChiKey: UUVBVONAGUSCCH-UHFFFAOYSA-N

物化性质

• 沸点：
  835.6±75.0 °C(Predicted)
• 密度：
  1.79±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  41
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  158
• 氢给体数：
  2
• 氢受体数：
  11

安全信息

• 安全说明：
  S22,S24/25
• WGK Germany：
  3

制备方法与用途

• 外观
  红色固体。

• 用途
  6-JOE 和 SE 具有与罗丹明 6G 相似的吸收和发射光谱，主要应用于自动 DNA 测序。此外，它还被用于标记核苷酸。

文献信息

• PHOTOACTIVATABLE ANTIMICROBIAL AGENTS AND THERAPEUTIC AND DIAGNOSTIC METHODS OF USING SAME
  申请人：Hasan Tayyaba

  公开号：US20110112059A1

  公开（公告）日：2011-05-12

  The present invention provides photosensitizer compounds for use in detecting beta-lactamase activity. Methods and kits that utilize the photosensitizer compounds of the invention for the detection of, quantitation of, and classification or typing of microbial beta-lactamases.

  本发明提供了用于检测β-内酰胺酶活性的光敏剂化合物。利用本发明的光敏剂化合物进行微生物β-内酰胺酶的检测、定量和分类或分型的方法和试剂盒。
• [EN] beta-LACTAMASE TARGETED PHOTOSENSITIZER FOR PESTICIDE AND PEST DETECTION<br/>[FR] PHOTOSENSIBILISATEUR CIBLÉ PAR LA Beta-LACTAMASE POUR PESTICIDE ET DÉTECTION D'ORGANISMES NUISIBLES
  申请人：GEN HOSPITAL CORP

  公开号：WO2013192521A1

  公开（公告）日：2013-12-27

  Photoactivatable pesticide compounds and methods for the use thereof in the elimination and detection of pests are provided.

  提供了用于消灭和检测害虫的光活化杀虫剂化合物及其使用方法。
• [EN] CARBOHYDRATE-DERIVATIZED LIPOSOMES FOR TARGETING CELLULAR CARBOHYDRATE RECOGNITION DOMAINS OF CTL/CTLD LECTINS, AND INTRACELLULAR DELIVERY OF THERAPEUTICALLY ACTIVE COMPOUNDS<br/>[FR] LIPOSOMES DERIVES D'HYDRATES DE CARBONE DESTINES A CIBLER DES DOMAINES DE RECONNAISSANCE D'HYDRATES DE CARBONE CELLULAIRES DE LECTINES CTL/CTLD, ET ADMINISTRATION INTRACELLULAIRE DE COMPOSES THERAPEUTIQUEMENT ACTIFS
  申请人：LET THERE BE HOPE MEDICAL RES

  公开号：WO2005092288A1

  公开（公告）日：2005-10-06

  Methods for preferentially delivering an active agent intracellularly to a reservoir cell that is infected with or susceptible to infection with an infectious agent, such as HIV. The active agent is part of a lipid-active agent complex that has a targeting ligand, such as a CTL/CTLD receptor-specific anchor, on its outer surface. Targeting systems are also disclosed. Such targeting systems are comprised of lipid-active agent complexes that contain targeting ligands, such as fucose and polyfucose derivatives, on their outer surfaces. The active agents include plant lectins, such as Con-A and MHL, and other drugs. Such methods and targeting systems may be used in the treatment of HIV and other infectious and non-infectious diseases.

  本发明涉及用于有选择地将活性剂向细胞内投递的方法，所述细胞是感染或易感染感染性剂（例如HIV）的储备细胞。所述活性剂是与脂质活性剂复合物的一部分，其外表面具有定位配体，例如CTL / CTLD受体特异性锚定。还公开了定位系统。这些定位系统由包含定位配体（例如岩藻糖和多岩藻糖衍生物）的脂质活性剂复合物组成，其外表面具有。活性剂包括植物凝集素，例如Con-A和MHL，以及其他药物。这些方法和定位系统可用于治疗HIV和其他传染性和非传染性疾病。
• Carbohydrate-Derivatized Liposomes for Targeting Cellular Carbohydrate Recognition Domains of Ctl/Ctld Lectins, and Intracellular Delivery of Therapeutically Active Compounds
  申请人：Gieseler K. Robert

  公开号：US20070292494A1

  公开（公告）日：2007-12-20

  Methods for preferentially delivering an active agent intracellularly to a reservoir cell that is infected with or susceptible to infection with an infectious agent, such as HIV. The active agent is part of a lipid-active agent complex that has a targeting ligand, such as a CTL/CTLD receptor-specific anchor, on its outer surface. Targeting systems are also disclosed. Such targeting systems are comprised of lipid-active agent complexes that contain targeting ligands, such as fucose and polyfucose derivatives, on their outer surfaces. The active agents include plant lectins, such as Con-A and MHL, and other drugs. Such methods and targeting systems may be used in the treatment of HIV and other infectious and non-infectious diseases.

  针对被感染或易感染某种传染病毒如HIV的储备细胞，提供一种优先将活性剂递送到细胞内的方法。活性剂是一种与脂质结合的复合物，其外表面具有定向配体，例如CTL/CTLD受体特异性锚定。还公开了定向系统，这些定向系统由包含定向配体（如富马醣和多富马醣衍生物）的脂质活性剂复合物组成。活性剂包括植物凝集素，如Con-A和MHL，以及其他药物。这些方法和定向系统可用于治疗HIV和其他传染性和非传染性疾病。
• BODIPY-LABELLED ENZYME SUBSTRATES AND METHODS USING THEM
  申请人：The General Hospital Corporation

  公开号：EP3056497A1

  公开（公告）日：2016-08-17

  The present invention provides photosensitizer compounds for use in detecting betalactamase activity. Methods and kits that utilize the photosensitizer compounds of the invention for the detection of quantitation of and classification or typing of microbial beta-lactamases.

  本发明提供了用于检测β-内酰胺酶活性的光敏剂化合物。利用本发明的光敏剂化合物对微生物 beta-内酰胺酶进行定量检测、分类或分型的方法和试剂盒。