6-脱氧-ALPHA-D-吡喃葡萄糖 1,2,3,4-四乙酸酯 | 24332-95-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 6-脱氧-ALPHA-D-吡喃葡萄糖 1,2,3,4-四乙酸酯
• 中文别名: 1,2,3,4-四-o-乙酰基-l-岩藻吡喃糖；6-脱氧-ALPHA-D-吡喃葡萄糖1,2,3,4-四乙酸酯
• 英文名称: (4,5,6-Triacetyloxy-2-methyloxan-3-yl) acetate
• CAS: 24332-95-4；7404-35-5；30021-94-4
• 化学式: C₁₄H₂₀O₉
• 分子量: 332.3
• InChiKey: QZQMGQQOGJIDKJ-UHFFFAOYSA-N

物化性质

• 沸点：
  371.4±42.0 °C(Predicted)
• 密度：
  1.26±0.1 g/cm3(Predicted)
• 溶解度：
  可溶于丙酮（少量）、氯仿（少量）、二氯甲烷（少量）、甲醇

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  114
• 氢给体数：
  0
• 氢受体数：
  9

安全信息

• 危险性防范说明：
  P261,P280,P301+P312,P302+P352,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

文献信息

• Preparation of Thiosugars and Their Use
  申请人：Davis Benjamin Guy

  公开号：US20090176970A1

  公开（公告）日：2009-07-09

  A process for the preparation of a thiosaccharide represented by Saccharide-S-H wherein Saccharide comprises at least 4 sugar units, comprises subjecting a corresponding compound of the formula (P)Saccharide-S-(P) wherein (P) represents an O- or S-protecting group(s), to Birch reduction.

  一种制备由糖硫代糖（Saccharide-S-H）表示的硫代糖的方法，其中糖代表至少4个糖单元，包括将具有以下结构的相应化合物（P）糖硫代糖（P）进行桦还原：（P）糖硫代糖（P），其中（P）代表一个或多个O-或S-保护基。
• Esters Of Glucuronide Prodrugs Of Anthracyclines And Method Of Preparation And Use In Tumor-Selective Chemotherapy
  申请人：Aben Rene Wilhelmus Marie

  公开号：US20090227617A1

  公开（公告）日：2009-09-10

  The invention relates to novel esters and in particular to some novel esters of glucuronide prodrugs of anthracyclines having tunable water-solubility, their synthesis and use in tumor-selective chemotherapy. It appeared that in the final step in the synthesis of these prodrugs, i.e. the coupling of the glucuronide spacer moiety to the parent drug molecule, protection of the sugar hydroxyls is, surprisingly, no longer required. A process for the preparation of these unprotected sugar spacer moieties is also disclosed.

  该发明涉及新型酯类化合物，特别是一些新型葡萄糖醛酸盐前药的酯类化合物，其具有可调节的水溶性，以及它们在肿瘤选择性化疗中的合成和应用。在这些前药的合成的最后一步中，即将葡萄糖醛酸盐间隔基与母药分子偶联时，令人惊讶的是，不再需要保护糖羟基。还公开了一种制备这些未保护糖间隔基的过程。
• Glycomimetic inhibitors of the PA-IL lectin, PA-IIL lectin or both the lectins from pseudomonas
  申请人：Magnani L. John

  公开号：US20070037775A1

  公开（公告）日：2007-02-15

  Compositions and methods are provided related to Pseudomonas bacteria. The compositions and methods may be used for diagnosis and therapy of medical conditions involving infection with Pseudomonas bacteria. Such infections include Pseudomonas aeruginosa in the lungs of patients with cystic fibrosis. A compound useful in the present methods may be used in combination with a therapeutic agent or may be linked to a therapeutic agent. Pseudomonas bacteria may be inhibited by blocking colonization, inhibiting virulence factors, arresting growth or killing the bacteria.

  提供与铜绿假单胞菌相关的组合物和方法。这些组合物和方法可用于诊断和治疗涉及铜绿假单胞菌感染的医疗状况。这些感染包括囊性纤维化患者肺部中的铜绿假单胞菌。在目前的方法中有用的化合物可以与治疗剂结合使用，或者可以与治疗剂连接。通过阻止定植、抑制毒力因子、阻止生长或杀死细菌可以抑制铜绿假单胞菌。
• Lectin-directed prodrug delivery system
  申请人：Davis Guy Benjamin

  公开号：US20070253942A1

  公开（公告）日：2007-11-01

  The invention provides a kit for lectin-directed prodrug delivery comprising a prodrug and a lectin-directed glycoconjugate, wherein the glycoconjugate is adapted to cleave the prodrug and thereby release the drug. The glycoconjugate generally comprises an enzyme conjugated to a carbohydrate moiety which binds to a lectin. The invention also provides novel glycoconjugates and novel methods of synthesizing prodrugs.

  本发明提供了一种用于凝集素定向前药递送的试剂盒，包括前药和凝集素定向的糖基结合物，其中糖基结合物适应于裂解前药并释放药物。糖基结合物通常包括与结合到凝集素的碳水化合物基团偶联的酶。本发明还提供了新型糖基结合物和新型合成前药的方法。
• Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells
  申请人：WONG CHI-HUEY

  公开号：US20080268468A1

  公开（公告）日：2008-10-30

  The present disclosure relates to a method for metabolic oligosaccharide engineering that incorporates derivatized alkyne-bearing sugar analogs as “tags” into cellular glycoconjugates. The disclosed method incorporates alkynyl derivatized Fuc and alkynyl derivatized ManNAc sugars into a cellular glycoconjugate. A chemical probe comprising an azide group and a visual probe or a fluorogenic probe is used to label the alkyne-derivatized sugar-tagged glycoconjugate. In one aspect, the chemical probe binds covalently to the alkynyl group by Cu(I)-catalyzed [3+2] azide-alkyne cycloaddition and is visualized at the cell surface, intracellularly, or in a cellular extract. The labeled glycoconjugate is capable of detection by flow cytometry, SDS-PAGE, Western blot, ELISA or confocal microscopy, and mass spectrometry.

  本公开涉及一种代谢寡糖工程的方法，该方法将衍生化的烷基糖类似物作为“标记”并纳入细胞糖蛋白中。所披露的方法将烷基化的Fuc和烷基化的ManNAc糖纳入细胞糖蛋白中。使用含有偶氮基团的化学探针和视觉探针或荧光探针来标记烷基化糖标记的糖蛋白。在一个方面，化学探针通过Cu(I)-催化的[3+2]偶氮-烷基环加成与烷基基团共价结合，并在细胞表面、细胞内或细胞提取物中可视化。标记的糖蛋白可通过流式细胞术、SDS-PAGE、Western blot、ELISA或共聚焦显微镜和质谱检测。