1-Methyl-4,7-dimethoxybenzimidazole-2-acetic acid-2'-13C methyl ester | 151920-67-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1-Methyl-4,7-dimethoxybenzimidazole-2-acetic acid-2'-13C methyl ester
• 英文别名: Methyl 2-(4,7-dimethoxy-1-methylbenzimidazol-2-yl)acetate
• CAS: 151920-67-1
• 化学式: C₁₃H₁₆N₂O₄
• 分子量: 265.27
• InChiKey: LKMOZPIEZKOKNN-KHWBWMQUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  62.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-Methyl-4,7-dimethoxybenzimidazole-2-acetic acid-2'-13C methyl ester 在 lithium aluminium tetrahydride 、 氢溴酸 、 三溴化磷 作用下， 以 乙醚 、 氯仿 为溶剂， 反应 9.0h， 生成 1-Methyl-2-(2'-bromoethyl)-4,7-dihydroxybenzimidazole hydrobromide-2'-13C
  参考文献：
  名称：

  A mechanistic study of 2-vinylbenzimidazole formation from 2-(2'-haloethyl)benzimidazoles. Synthesis of highly electron-rich vinylic compounds by general base and specific acid-general base catalysis

  摘要：

  The mechanism of halide elimination from 2-(haloethyl)-1-methyl-4,7-dihydroxybenzimidazole was studied in aqueous buffer by means of a pH-rate profile, buffer dilution studies, and C-13 scrambling. It was anticipated that a spiro-fused cyclopropyl species could arise from the above benzimidazole derivative by loss of HX. However, the results of our studies were consistent with both the general base and the specific acid/general base-catalyzed 1,2-elimination of HX. Since the loss of the leaving group occurs in the same transition state as proton abstraction, the elimination mechanism is of the ''E2'' type. The specific acid/general base process permits facile elimination reactions in acidic (pH < 6) media. Thus, protonation of the benzimidazole nitrogen (specific acid) at low pH electrostatically favors proton abstraction by the general base (acetate and phosphate).

  DOI：

  10.1021/jo00079a025
• 作为产物：
  描述：

  1-Methyl-2-(cyanomethyl)-4,7-dimethoxybenzimidazole-2'-13C 在 硫酸 作用下， 反应 5.0h， 生成 1-Methyl-4,7-dimethoxybenzimidazole-2-acetic acid-2'-13C methyl ester
  参考文献：
  名称：

  A mechanistic study of 2-vinylbenzimidazole formation from 2-(2'-haloethyl)benzimidazoles. Synthesis of highly electron-rich vinylic compounds by general base and specific acid-general base catalysis

  摘要：

  The mechanism of halide elimination from 2-(haloethyl)-1-methyl-4,7-dihydroxybenzimidazole was studied in aqueous buffer by means of a pH-rate profile, buffer dilution studies, and C-13 scrambling. It was anticipated that a spiro-fused cyclopropyl species could arise from the above benzimidazole derivative by loss of HX. However, the results of our studies were consistent with both the general base and the specific acid/general base-catalyzed 1,2-elimination of HX. Since the loss of the leaving group occurs in the same transition state as proton abstraction, the elimination mechanism is of the ''E2'' type. The specific acid/general base process permits facile elimination reactions in acidic (pH < 6) media. Thus, protonation of the benzimidazole nitrogen (specific acid) at low pH electrostatically favors proton abstraction by the general base (acetate and phosphate).

  DOI：

  10.1021/jo00079a025

文献信息

• A mechanistic study of 2-vinylbenzimidazole formation from 2-(2'-haloethyl)benzimidazoles. Synthesis of highly electron-rich vinylic compounds by general base and specific acid-general base catalysis
  作者：Romesh C. Boruah、Edward B. Skibo

  DOI：10.1021/jo00079a025

  日期：1993.12

  The mechanism of halide elimination from 2-(haloethyl)-1-methyl-4,7-dihydroxybenzimidazole was studied in aqueous buffer by means of a pH-rate profile, buffer dilution studies, and C-13 scrambling. It was anticipated that a spiro-fused cyclopropyl species could arise from the above benzimidazole derivative by loss of HX. However, the results of our studies were consistent with both the general base and the specific acid/general base-catalyzed 1,2-elimination of HX. Since the loss of the leaving group occurs in the same transition state as proton abstraction, the elimination mechanism is of the ''E2'' type. The specific acid/general base process permits facile elimination reactions in acidic (pH < 6) media. Thus, protonation of the benzimidazole nitrogen (specific acid) at low pH electrostatically favors proton abstraction by the general base (acetate and phosphate).