2-Amino-3-(4-propoxyphenyl)propanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Amino-3-(4-propoxyphenyl)propanoic acid
• 化学式: C₁₂H₁₇NO₃
• 分子量: 223.27
• InChiKey: WIDNDXOANCQXPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  72.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• NOVEL IMIDES
  申请人：CELGENE CORPORATION

  公开号：EP0706521A1

  公开（公告）日：1996-04-17
• COMPOSITIONS AND METHODS FOR CELLULAR IMAGING AND THERAPY
  申请人：The Board of Regents of The University of Texas System

  公开号：EP2013221B1

  公开（公告）日：2015-06-24
• Compositions Containing, Methods Involving, and Uses of Non-Natural Amino Acid Linked Dolastatin Derivatives
  申请人：AMBRX, INC.

  公开号：US20150080559A1

  公开（公告）日：2015-03-19

  Disclosed herein are non-natural amino acids and dolastatin analogs that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The dolastatin analogs can include a wide range of possible functionalities, but typically have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid dolastatin analogs that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such dolastatin analogs. Typically, the modified dolastatin analogs include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid dolastatin analogs and modified non-natural amino acid dolastatin analogs, including therapeutic, diagnostic, and other biotechnology uses.
• Anti-PSMA Antibodies Conjugated to Nuclear Receptor Ligand Polypeptides
  申请人：Ambrx, Inc.

  公开号：US20150152187A1

  公开（公告）日：2015-06-04

  This invention relates to anti-prostate-specific membrane antigen antibodies (αPSMA) and αPSMA antibody—nuclear receptor ligand (NRL) conjugates comprising at least one non-naturally-encoded amino acid.
• Anti-CD70 Antibody Drug Conjugates
  申请人：Ambrx, Inc.

  公开号：US20150141624A1

  公开（公告）日：2015-05-21

  This invention relates to anti-CD70 antibodies and antibody drug conjugates comprising at least one non-naturally-encoded amino acid. Disclosed herein are αCD70 antibodies with one or more non-naturally encoded amino acids and further disclosed are antibody drug conjugates wherein the αCD70 antibodies of the invention are conjugated to one or more toxins. Further disclosed are methods for using such non-natural amino acid antibody drug conjugates, including therapeutic, diagnostic, and other biotechnology uses.