2-Propenamide, N-[2-(diethylamino)ethyl]-N,2-dimethyl-

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Propenamide, N-[2-(diethylamino)ethyl]-N,2-dimethyl-
• 英文别名: N-[2-(diethylamino)ethyl]-N,2-dimethylprop-2-enamide
• 化学式: C₁₁H₂₂N₂O
• 分子量: 198.31
• InChiKey: HHSZSTNZSRJWAI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Polymeric prodrugs and subcutaneous and/or intramuscular administration thereof
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

  公开号：US20200353090A1

  公开（公告）日：2020-11-12

  The invention relates to new prodrugs of active molecules. These prodrugs allow, in particular, the subcutaneous or intramuscular administration of active molecules of which the subcutaneous or intramuscular administration is problematic or impossible, in particular because of the toxicity at the injection site. The prodrugs according to the invention comprise an active ingredient, covalently linked with a polymer chain, preferably a hydrophilic and/or thermosensitive polymer chain. The invention relates, in particular, to polymeric prodrugs comprising a polymer chain formed at least in part by acrylamide monomer or one of its derivatives, the polymer comprising a proximal part and a terminal part; a first pharmaceutically active molecule covalently coupled to the proximal part of the polymer; possibly a second pharmaceutically active molecule covalently coupled to the terminal part of the polymer.

  该发明涉及新型活性分子的前药。这些前药允许特别是将活性分子皮下或肌肉内注射，而这些活性分子的皮下或肌肉内注射由于在注射部位的毒性而具有问题或不可能，特别是由于在注射部位的毒性。根据本发明的前药包括一种活性成分，与一根聚合物链共价连接，优选为一种亲水性和/或热敏感性聚合物链。该发明特别涉及包括由丙烯酰胺单体或其衍生物之一至少部分形成的聚合物链的聚合物前药，该聚合物包括一个近端部分和一个末端部分；第一种药用活性分子共价结合到聚合物的近端部分；可能第二种药用活性分子共价结合到聚合物的末端部分。
• PRODROGUES POLYMÈRES ET LEUR ADMINISTRATION SOUS-CUTANEE ET/OU INTRAMUSCULAIRE
  申请人：Centre National de la Recherche Scientifique

  公开号：EP3710061A1

  公开（公告）日：2020-09-23
• LIPID NANOPARTICLES
  申请人：ModernaTX, Inc.

  公开号：US20200315967A1

  公开（公告）日：2020-10-08

  The invention features methods and apparatus for producing lipid nanoparticles. Methods of the invention include injecting a lipid solution into an aqueous solution at an automated rate (e.g., a rate controlled by a servo pump). The invention provides methods and apparatus for making lipid nanoparticles possessing a wide range of lipid components and hydrophilic encapsulants, including nucleic acids (e.g., mRNA). Also provided are nanoparticles and compositions thereof made by methods and apparatus of the invention.
• [EN] LIPID NANOPARTICLES<br/>[FR] NANOPARTICULES LIPIDIQUES
  申请人：MODERNATX INC

  公开号：WO2017223135A1

  公开（公告）日：2017-12-28

  The invention features methods and apparatus for producing lipid nanoparticles. Methods of the invention include injecting a lipid solution into an aqueous solution at an automated rate (e.g., a rate controlled by a servo pump). The invention provides methods and apparatus for making lipid nanoparticles possessing a wide range of lipid components and hydrophilic encapsulants, including nucleic acids (e.g., mRNA). Also provided are nanoparticles and compositions thereof made by methods and apparatus of the invention.
• [EN] RUBBER COMPOSITION AND METHOD FOR PRODUCING RUBBER COMPOSITION<br/>[FR] COMPOSITION DE CAOUTCHOUC ET PROCÉDÉ DE PRODUCTION DE COMPOSITION DE CAOUTCHOUC<br/>[JA] ゴム組成物及びゴム組成物を製造する方法
  申请人：ZS ELASTOMERS CO LTD

  公开号：WO2020196892A1

  公开（公告）日：2020-10-01

  ゴム成分、添加剤及び充填剤を含むゴム組成物であり、添加剤は、ケイ素原子、窒素原子及び酸素原子からなる群より選ばれる少なくとも１種の原子と、炭素原子とを含む化合物を含有し、化合物を構成するケイ素原子、窒素原子及び酸素原子の総数が、炭素原子数に対して０．２７以上０．８０以下であり、化合物のハンセン溶解度パラメータが下記式（２）で表される関係を満足し、化合物の分子量が２００以上１５０００以下である。 ６≦｛４（δＤ１－δＤ２）２＋（δＰ１－δＰ２）２＋（δＨ１－δＨ２）２｝０．５　（２）