diethyl 2-benzyl-3-ketoglutarate | 54813-93-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: diethyl 2-benzyl-3-ketoglutarate
• 英文别名: 2-benzyl-3-oxo-pentanedioic acid diethyl ester；2-benzyl-3-oxo-glutaric acid diethyl ester；2-Benzyl-3-oxo-glutarsaeure-diaethylester；ethyl 2-benzyl-3-oxopentanedioate；2-Benzyl-3-ketoglutarate diethyl ester；diethyl 2-benzyl-3-oxopentanedioate
• CAS: 54813-93-3
• 化学式: C₁₆H₂₀O₅
• 分子量: 292.332
• InChiKey: HZOCADZQLFGJLU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  21
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  69.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  diethyl 2-benzyl-3-ketoglutarate 以60%的产率得到
  参考文献：
  名称：

  ITO I.; NAGAI S., CHEM. AND PHARM. BULL. , 1974, 22, NO 9, 2131-2135

  摘要：

  DOI：
• 作为产物：
  描述：

  1,3-丙酮二羧酸二甲酯 生成 diethyl 2-benzyl-3-ketoglutarate
  参考文献：
  名称：

  ITO I.; NAGAI S., CHEM. AND PHARM. BULL. , 1974, 22, NO 9, 2131-2135

  摘要：

  DOI：

文献信息

• DERIVATIVES OF 2-PYRIDIN-2-YL-PYRAZOL-3(2H)-ONE, PREPARATION AND THERAPEUTIC USE THEREOF AS HIF ACTIVATORS
  申请人：ALTENBURGER Jean-Michel

  公开号：US20110294788A1

  公开（公告）日：2011-12-01

  The present invention relates to novel substituted dihydropyrazolone derivatives, to their preparation and to their therapeutic use as activators of the transcription factor HIF.

  本发明涉及新型取代二氢吡唑酮衍生物，其制备以及作为转录因子HIF激活剂的治疗用途。
• Methods for producing hydroxy amino acids and derivatives thereof
  申请人：Rozzell David J.

  公开号：US20050100993A1

  公开（公告）日：2005-05-12

  Hydroxy-amino acids are provided and are prepared by contacting a substituted P-ketodiester having a ketone group and two ester functional groups with a ketoreductase under conditions permitting the reduction of the keytone group to an alcohol. Only one of the ester functional groups is regioselectively hydrolyzed to the corresponding carboxylic acid, whereby a non-hydrolyzed ester functional group remains. The carboxylic acid is converted to an amine to produce a hydroxy-amino acid.

  提供了羟基氨基酸，并通过将具有酮基和两个酯官能团的取代P-酮二酯与酮还原酶接触，在条件允许酮基还原为醇的情况下制备。仅选择性水解其中一个酯官能团为相应的羧酸，从而保留未水解的酯官能团。将羧酸转化为胺以产生羟基氨基酸。
• Methods for producing hydroxy amino acids, esters, and derivatives thereof
  申请人：Rozzell David J.

  公开号：US20050192439A1

  公开（公告）日：2005-09-01

  A method for producing a hydroxy-amino ester, or derivative thereof, is provided. A substituted β-ketodiester having a ketone group and two ester functional groups is contacted with a ketoreductase under conditions permitting the reduction of the ketone group to an alcohol. Only one of the ester functional groups is regioselectively hydrolyzed to the corresponding carboxylic acid, whereby a non-hydrolyzed ester functional group remains. The carboxylic acid is converted to an amine or a derivative thereof to produce a hydroxy-amino ester or derivative thereof. A number of novel hydroxy-amino esters are prepared by the method.

  提供了一种制备羟基-氨基酯或其衍生物的方法。将具有酮基和两个酯基官能团的取代β-酮二酯与酮还原酶接触，并在条件允许的情况下将酮基还原为醇。仅对其中一个酯基官能团进行区域选择性水解成相应的羧酸，从而保留了一个未水解的酯基官能团。将羧酸转化为胺或其衍生物，以产生羟基-氨基酯或其衍生物。通过该方法制备了许多新型羟基-氨基酯。
• Derivatives of 2-pyridin-2-yl-pyrazol-3(2H)-one, preparation and therapeutic use thereof as HIF activators
  申请人：Altenburger Jean-Michel

  公开号：US08541455B2

  公开（公告）日：2013-09-24

  The present invention relates to novel substituted dihydropyrazolone derivatives, to their preparation and to their therapeutic use as activators of the transcription factor HIF.

  本发明涉及新型取代二氢吡唑酮衍生物，其制备方法及其作为转录因子HIF的激活剂的治疗用途。
• Hydroxy-amino acids
  申请人：BioCatalytics, Inc.

  公开号：US07081535B2

  公开（公告）日：2006-07-25

  Hydroxy-amino acids are provided and are prepared by contacting a substituted β-ketodiester having a ketone group and two ester functional groups with a ketoreductase under conditions permitting the reduction of the keytone group to an alcohol. Only one of the ester functional groups is regioselectively hydrolyzed to the corresponding carboxylic acid, whereby a non-hydrolyzed ester functional group remains. The carboxylic acid is converted to an amine to produce a hydroxy-amino acid.

  提供了羟基氨基酸，并通过将具有酮基和两个酯功能基的取代β-酮二酯与酮还原酶接触，在允许酮基还原为醇的条件下制备。只有一个酯功能基被区域选择性水解为相应的羧酸，其中保留了未水解的一个酯功能基。羧酸被转化为胺以产生羟基氨基酸。