4-acetyl-3-hydroxy-1-methylspiro[2,5-dihydropyrrol-5,3'-indole]-2,2'-dione | 893773-15-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-acetyl-3-hydroxy-1-methylspiro[2,5-dihydropyrrol-5,3'-indole]-2,2'-dione
• 英文别名: 4'-acetyl-3'-hydroxy-1'-methylspiro[1H-indole-3,5'-pyrrole]-2,2'-dione
• CAS: 893773-15-4
• 化学式: C₁₄H₁₂N₂O₄
• 分子量: 272.26
• InChiKey: BEFAJALHJNWUOG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  86.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  靛红 、 乙酰丙酮酸甲酯 、 甲胺 以 1,4-二氧六环 、 水 为溶剂， 以47%的产率得到4-acetyl-3-hydroxy-1-methylspiro[2,5-dihydropyrrol-5,3'-indole]-2,2'-dione
  参考文献：
  名称：

  Three-component synthesis of 1-substituted 4-acetyl-3-hydroxyspiro[2,5-dihydropyrrol-5,3′-indole]-2,2′-diones

  摘要：

  DOI：

  10.1007/s10593-008-0085-6

文献信息

• [EN] COMPOUNDS COMPRISING 1,1',2,5'-TETRAHYDROSPIRO[INDOLE-3,2'-PYRROLE]-2,5'-DIONE SYSTEM AS INHIBITORS P53-MDM2 PROTEIN-PROTEIN INTERACTION<br/>[FR] COMPOSÉS COMPRENANT UN SYSTÈME 1,1',2,5'-TÉTRAHYDROSPIRO[INDOLE-3,2'-PYRROLE]-2,5'-DIONE EN TANT QU'INHIBITEURS DE L'INTERACTION PROTÉINE-PROTÉINE DE P53-MDM2
  申请人：ADAMED SP ZOO

  公开号：WO2015189799A1

  公开（公告）日：2015-12-17

  A spirooxoindole compound represented by the formula selected from the group consisting of Formula (IA) and (IB), wherein all symbols are as defined in the description. The compound can find use in a method of prevention and/or treatment of diseases selected from the group consisting of cancer, immune diseases, inflammatory conditions, allergic skin diseases associated with excessive proliferation, and viral infections.

  一种由以下公式组成的螺环氧吲哚化合物，其中所有符号均如描述中所定义。该化合物可用于预防和/或治疗来自癌症、免疫疾病、炎症症状、与过度增殖相关的过敏性皮肤疾病以及病毒感染的疾病组中所选的方法。
• COMPOUNDS COMPRISING 1,1',2,5'-TETRAHYDROSPIRO[INDOLE-3,2'-PYRROLE]-2,5'-DIONE SYSTEM AS INHIBITORS P53-MDM2 PROTEIN-PROTEIN INTERACTION
  申请人：Adamed sp. z o.o.

  公开号：EP3154982A1

  公开（公告）日：2017-04-19
• COMPOUNDS COMPRISING 1,1a,2,5a-TETRAHYDROSPIRO[INDOLE-3,2a-PYRROLE]-2,5a-DIONE SYSTEM AS INHIBITORS P53-MDM2 PROTEIN-PROTEIN INTERACTION
  申请人：ADAMED SP. Z O.O.

  公开号：US20170129903A1

  公开（公告）日：2017-05-11

  A spirooxoindole compound represented by the formula selected from the group consisting of formula (IA) and (IB), wherein all symbols are as defined in the description. The compound can find use in a method of prevention and/or treatment of diseases selected from the group consisting of cancer, immune diseases, inflammatory conditions, allergic skin diseases associated with excessive proliferation, and viral infections.
• Three-component synthesis of 1-substituted 4-acetyl-3-hydroxyspiro[2,5-dihydropyrrol-5,3′-indole]-2,2′-diones
  作者：V. L. Gein、L. F. Gein、E. D. Kuznetsova、M. A. Sheptukha、E. P. Tsypliakova、K. D. Potiemkin

  DOI：10.1007/s10593-008-0085-6

  日期：2008.5