7,7,9,9-四甲基-1,3,8-三氮杂螺[4.5]-2,4-癸二酮 | 15871-54-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 中文名称: 7,7,9,9-四甲基-1,3,8-三氮杂螺[4.5]-2,4-癸二酮
• 中文别名: 7,7,9,9-四甲基-1,3,8-三氮杂螺[4,5]癸烷-2,4-二酮
• 英文名称: 2',5'-Dioxo-2,2,6,6-tetramethyl-piperidin-(4-spiro-4')-imid-azolidin
• 英文别名: 1,3,8-triaza-7,7,9,9-tetramethyl-spiro[4.5]decane-2,4-dione；7,7,9,9-tetramethyl-1,3,8-triazaspiro[4.5]decane-2,4-dione；7,7,9,9-Tetramethyl-1,3,8-triaza-spiro[4.5]decan-2,4-dion
• CAS: 15871-54-2
• 化学式: C₁₁H₁₉N₃O₂
• mdl: MFCD00134335
• 分子量: 225.291
• InChiKey: PNJCQCUNRRANAF-UHFFFAOYSA-N

物化性质

• 熔点：
  >300 °C(lit.)
• 密度：
  1.17±0.1 g/cm3(Predicted)
• 稳定性/保质期：

  按规定使用和贮存的这些物质不会分解，并且能够避免与氧化物接触。

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.818
• 拓扑面积：
  70.2
• 氢给体数：
  3
• 氢受体数：
  3

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S37/39
• 危险类别码：
  R36/37/38
• 海关编码：
  2933990090
• 储存条件：
  请将药品存放在密闭、阴凉、干燥的地方。

反应信息

• 作为反应物：
  描述：

  7,7,9,9-四甲基-1,3,8-三氮杂螺[4.5]-2,4-癸二酮 在 氢氧化钾 作用下， 以 甲醇 、 水 、 xylene 为溶剂， 生成 7,7,9,9-tetramethyl-1,3,8-triazaspiro[4.5]decane-2,4-dione
  参考文献：
  名称：

  WO2008/98877

  摘要：

  公开号：
• 作为产物：
  描述：

  四甲基哌啶酮 、 氰化钾 、 alkaline earth salt of/the/ methylsulfuric acid 在 乙醇 作用下， 生成 7,7,9,9-四甲基-1,3,8-三氮杂螺[4.5]-2,4-癸二酮
  参考文献：
  名称：

  Synthesis of Derivatives of Alkylated and Arylated Piperidones and Piperidinols

  摘要：

  DOI：

  10.1021/jo01360a017

文献信息

• Hydantoin derivatives and their use as polymer stabilizers
  申请人：Sankyo Company Limited

  公开号：US04162246A1

  公开（公告）日：1979-07-24

  Hydantoin derivatives in which two or three piperidine spiro hydantoin residues are attached by means of substituted alkylene groups or polyoxyalkylene groups whose oxyalkylene chain is optionally interrupted by one or more phenylene or cyclohexylene groups or by means of substituted isocyanurate or glyceryl groups and, where they exist, acid addition salts thereof, are valuable as stabilizers for synthetic polymers.

  咪唑啉螺内酰脲衍生物，其中通过取代的烷基或聚氧烷基将两个或三个哌啶螺内酰脲残基连接在一起，其氧烷基链可以选择性地被一个或多个苯基或环己基组分隔，或者通过取代的异氰酸酯或甘油基连接在一起，以及存在时的酸盐加合物，对于合成聚合物的稳定剂具有重要价值。
• [EN] ANTIMICROBIAL OXAZOLIDINONE, HYDANTOIN AND IMIDAZOLIDINONE COMPOSITIONS<br/>[FR] COMPOSITIONS ANTIMICROBIENNES D'OXAZOLIDINONE, D'HYDANTOÏNE ET D'IMIDAZOLIDINONE
  申请人：NOVABAY PHARMACEUTICALS INC

  公开号：WO2010054009A1

  公开（公告）日：2010-05-14

  The present application relates to N-chlorinated oxazolidinone, hydantoin and imidazolidinone compounds of Formula (I): or pharmaceutically acceptable salts thereof, and associated compositions and methods of use as antimicrobial agents.

  本申请涉及Formula (I)中的N-氯代噁唑烷二酮、海因酮和咪唑烷二酮化合物，或其药用可接受的盐，以及相关的组合物和用作抗微生物剂的方法。
• Biocidal N-Halamine epoxides
  申请人：Worley S.D.

  公开号：US20070015921A1

  公开（公告）日：2007-01-18

  N-halaminehydantoinyl epoxide compounds which can be used for the construction of coatings and materials which can be rendered biocidal by exposure to halogen solutions either before or after curing the coating or material are disclosed. The biocidal coatings and materials can then be used to inactivate pathogenic microorganisms such as bacteria, fungi, and yeasts, as well as virus particles, which can cause infectious diseases, and those microorganisms which cause noxious odors and unpleasant coloring such as mildew. The coatings are compatible with a variety of substrates including, but not limited to, cellulose, chitin, chitosan, synthetic fibers, cement grout, latex caulk, acrylic films, polyurethanes, plastics and paints.

  本发明揭示了可用于构建涂层和材料的N-卤胺嘧啶基环氧化合物，通过暴露于卤素溶液中，无论是在涂层或材料固化之前还是之后，这些涂层和材料可以被赋予生物杀菌性能。这些生物杀菌涂层和材料可以用于灭活病原微生物，如细菌、真菌、酵母以及病毒颗粒，这些微生物可能引起传染病，以及那些引起恶臭和不愉快变色的微生物，如霉菌。这些涂层与各种基材兼容，包括但不限于纤维素、壳聚糖、壳聚糖、合成纤维、水泥灰浆、乳胶灌缝剂、丙烯酸膜、聚氨酯、塑料和油漆。
• Piperidine derivatives
  申请人：Sankyo Company Limited

  公开号：US04241208A1

  公开（公告）日：1980-12-23

  Piperidine derivatives having the formula ##STR1## wherein R' represents an alkyl, an acyl, an alkoxycarbonyl, an amino or nitroso group; X represents oxygen or sulfur; Y represents oxygen, sulfur or a group of the formula .dbd.N--R" in which R" is hydrogen or alkyl; Z represents oxygen or a group of the formula >N--R'" in which R'" is hydrogen or alkyl; n is an integer of 1 to 4; and R represents, when n is 1, alkyl, aryl, cycloalkyl, alkoxycarbonyl, substituted phosphino or substituted phosphinyl, when n is 2, alkylene, alkenylene, arylene, aralkylene; alkylenediphenylene, bis-(alkoxycarbonyl) alkylene, alkylene-bis-(oxycarbonylalkyl), dialkylene ether or diphenylene ether, when n is 3, alkanetriyl,tris-(alkoxycarbonyl)alkanetriyl, alkanetriyl-tris-(oxycarbonylalkyl) or a group of the formula ##STR2## in which p is an integer of 1 through 8 inclusive, and, when n is 4, alkanetetrayl,tetrakis-(alkoxycarbonyl) alkanetetrayl or alkanetetrayl-tetrakis-(oxycarbonylalkyl). The piperidine derivatives (I) of this invention are prepared in various manners and useful as stabilizers for synthetic polymers against thermal- and photo-deterioration thereof. A typical example of such a stabilizer is 1,3,8-triaza-3,8-dibenzyl-1,7,7,9,9-pentamethyl-spiro[4.5]decane-2,4-dione .

  具有以下式子的哌啶衍生物：##STR1## 其中，R'代表烷基，酰基，烷氧羰基，氨基或亚硝基；X代表氧或硫；Y代表氧，硫或公式.dbd.N--R"的基团，其中R"为氢或烷基；Z代表氧或公式>N--R'"的基团，其中R'"为氢或烷基；n为1到4的整数；当n为1时，R代表烷基，芳基，环烷基，烷氧羰基，取代的膦或取代的膦酰基；当n为2时，R代表烷基，烯基，芳基，芳基烷基，烷基二苯基，双（烷氧羰基）烷基，烷基双（氧羰基烷基），二烷基醚或二苯基醚；当n为3时，R代表烷基三基，三（烷氧羰基）烷基三基，烷基三基（氧羰基烷基）或公式##STR2## 其中p为1到8的整数；当n为4时，R代表烷基四基，四（烷氧羰基）烷基四基或烷基四基（氧羰基烷基）。本发明的哌啶衍生物（I）以各种方式制备，可用作合成高分子材料的稳定剂，以防止其热和光降解。这种稳定剂的典型例子是1,3,8-三氮杂-3,8-二苯基-1,7,7,9,9-五甲基-螺[4.5]癸烷-2,4-二酮。
• [EN] NEW STERICALLY HINDERED POLYMERIC AMINES AND THEIR USE AS POLYMER STABILIZERS<br/>[FR] NOUVELLES AMINES POLYMÈRES ENCOMBRÉES ET LEUR UTILISATION COMME STABILISATEURS DE POLYMÈRES
  申请人：3V SIGMA SPA

  公开号：WO2012055965A1

  公开（公告）日：2012-05-03

  The present invention relates to polypiperidine compounds of polymeric type which are capable of conferring to the polymeric materials, particularly to polyolefins, a high stability against photodegradation and oxidative action of air, belong to the HALS category and have general formula (I): wherein p is from 3 to 20; n is from 2 to 12; R and R1, which are the same or different, are selected in the group consisting of hydrogen, linear and branched C1-C12 alkyl groups, alkenyl groups having 3 to 8 carbon atoms and aralkyl groups having 7 to 19 carbon atoms; X and X1, which are the same or different, are selected in the group consisting of oxygen and groups of formula (II) wherein R2 is selected in the group consisting of hydrogen, linear and branched C1-C12 alkyl groups, cycloalkyl groups having 5 to 12 carbon atoms and aralkyl groups having 7 to 12 carbon atoms; A represents a –(CH2)a– group wherein a is from 2 to 12, with the proviso that a is different from n; Z is selected in the group consisting of C1-C18 alkyl groups, groups of formula (III) wherein n, X, X1, R and R1 are as above defined, and groups of formula (IV) wherein R is as above defined; Y represents a substituent selected in the group consisting of the groups of general formula (V) the groups O-R4 and S-R4, wherein R3 and R4, which may be the same or different, represent hydrogen, a linear and branched C1-C18 alkyl group, a cycloakyl group having 5 to 12 carbon atoms, an aralkyl group having 7 to 12 carbon atoms, an aryl group having 6 to 12 carbon atoms or may form, together with the nitrogen atom to which they are linked, a heterocycle containing 5 to 7 carbon atoms; and the piperidine group (VI) wherein R and X are as above defined. The invention further relates to the processes for preparation of the compounds according to the invention.

  本发明涉及聚合型多吡咯烷化合物，能够赋予聚合材料，特别是聚烯烃，高稳定性，抵抗光降解和空气氧化作用，属于HALS类，并具有通式（I）：其中p为3到20；n为2到12；R和R1相同或不同，选择在氢、线性和支链C1-C12烷基、具有3到8个碳原子的烯基基团和具有7到19个碳原子的芳基烷基中；X和X1相同或不同，选择在氧和式（II）中的基团，其中R2选择在氢、线性和支链C1-C12烷基、具有5到12个碳原子的环烷基和具有7到12个碳原子的芳基烷基中；A代表-（CH2）a-基团，其中a为2到12，但a与n不同；Z选择在C1-C18烷基、式（III）中的基团，其中n、X、X1、R和R1如上所述，以及式（IV）中的基团，其中R如上所述；Y代表在通式（V）的基团、O-R4和S-R4的基团中选择，其中R3和R4相同或不同，表示氢、线性和支链C1-C18烷基、具有5到12个碳原子的环烷基、具有7到12个碳原子的芳基烷基、具有6到12个碳原子的芳基基团，或者与它们连接的氮原子一起形成含有5到7个碳原子的杂环；以及哌啶基（VI），其中R和X如上所述。本发明还涉及根据本发明制备化合物的方法。