2-Chloro-3-(2-phenylethylsulfanyl)pyrazine | 942910-22-7

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2-Chloro-3-(2-phenylethylsulfanyl)pyrazine
• CAS: 942910-22-7
• 化学式: C₁₂H₁₁ClN₂S
• 分子量: 250.752
• InChiKey: NXSVXLLMPPZZJW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  51.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-Chloro-3-(2-phenylethylsulfanyl)pyrazine 在 sodium hydroxide 、 水 、 二甲基亚砜 作用下， 反应 0.5h， 以12%的产率得到3-(phenethylthio)pyrazin-2(1H)-one
  参考文献：
  名称：

  WO2007/71646

  摘要：

  公开号：
• 作为产物：
  描述：

  2,3-二氯吡嗪 在 sodium hydride 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 0.67h， 以72%的产率得到2-Chloro-3-(2-phenylethylsulfanyl)pyrazine
  参考文献：
  名称：

  WO2007/71646

  摘要：

  公开号：

文献信息

• NOVEL SUBSTITUTED PYRAZINONE DERIVATIVES FOR USE IN MCH-1 MEDIATED DISEASES
  申请人：Janssen Pharmaceutica N.V.

  公开号：EP1966164B1

  公开（公告）日：2013-03-06
• Novel Substituted Pyrazinone Derivatives for Use in Mch-1 Mediated Diseases
  申请人：Andres-Gil Jose Ignacio

  公开号：US20090012062A1

  公开（公告）日：2009-01-08

  The present invention concerns aryl and heteroaryl substituted pyrazinone derivatives having antagonistic melanin-concentrating hormone (MCH) activity, in particular MCH-1 activity according to the general Formula (I) a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, wherein the variables are defined in Claim 1 . It further relates to their preparation, compositions comprising them and their use as a medicine. The compounds according to the invention are useful for the prevention and/or treatment of psychiatric disorders, including but not limited to anxiety, eating disorders, mood disorders, such as bipolar disorders and depression, psychoses, such as schizophrenia, and sleeping disorders; obesity; diabetes; sexual disorders and neurological disorders.
• US8329704B2
  申请人：——

  公开号：US8329704B2

  公开（公告）日：2012-12-11
• [EN] NOVEL SUBSTITUTED PYRAZINONE DERIVATIVES FOR USE IN MCH-1 MEDIATED DISEASES<br/>[FR] NOUVEAUX DERIVES DE PYRAZINONE SUBSTITUEE A UTILISER LORS DE MALADIES MEDIEES PAR MCH-1
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2007071646A1

  公开（公告）日：2007-06-28

  [EN] The present invention concerns aryl and heteroaryl substituted pyrazinone derivatives having antagonistic melanin-concentrating hormone (MCH) activity, in particular MCH-I activity according to the general Formula (I) a pharmaceutically acceptable acid or base addition salt thereof, a stereo chemically isomeric form thereof, an TV-oxide form thereof or a quaternary ammonium salt thereof, wherein the variables are defined in Claim 1. It further relates to their preparation, compositions comprising them and their use as a medicine. The compounds according to the invention are usefull for the prevention and/or treatment of psychiatric disorders, including but not limited to anxiety, eating disorders, mood disorders, such as bipolar disorders and depression, psychoses, such as schizophrenia, and sleeping disorders ; obesity ; diabetes ; sexual disorders and neurological disorders.
  [FR] L'invention concerne des dérivés de pyrazinone substituée par aryle et hétéroaryle présentant une activité d'hormone de concentration en mélanine (MCH) antagoniste, en particulier une activité de MCH-1 selon la formule générale (I), un sel d'addition d'acide ou de base, une forme stéréo-chimiquement isomère, une forme deN-oxyde ou un sel d'ammonium quaternaire de ceux-ci pharmaceutiquement acceptable, dont les paramètres sont définis dans la Revendication 1. L'invention concerne en outre la préparation de ces dérivés, les compositions les renfermant et leur utilisation comme médicament. Les composés selon l'invention servent à prévenir et/ou à traiter des troubles psychiatriques, notamment l'anxiété, les troubles de l'alimentation, les troubles de l'humeur, par exemple les troubles bipolaires et la dépression, les psychoses, par exemple la schizophrénie, et les troubles du sommeil; l'obésité; les diabètes; les troubles sexuels et les troubles neurologiques.