1-(4-hydroxyphenyl)-6-methyluracil | 84455-90-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-(4-hydroxyphenyl)-6-methyluracil
• 英文别名: 1-(4-hydroxyphenyl)-6-methylpyrimidine-2,4(1H,3H)-dione；1-(4-hydroxyphenyl)-6-methylpyrimidine-2,4-dione
• CAS: 84455-90-3
• 化学式: C₁₁H₁₀N₂O₃
• 分子量: 218.212
• InChiKey: ZGTSPPMDSSMCPY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  69.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-(4-hydroxyphenyl)-2-thio-6-methyluracil 在 高氯酸 作用下， 以 溶剂黄146 为溶剂， 反应 7.0h， 以66%的产率得到1-(4-hydroxyphenyl)-6-methyluracil
  参考文献：
  名称：

  Synthesis and transformations of 1-(4-hydroxyphenyl)dihydrouracils

  摘要：

  DOI：

  10.1007/bf00503202

文献信息

• Heterocyclic transformations. Part 5: Studies in reactions of 6-methyl -l,3-oxazine-2,4(3H)-dione with arylamines—a facile synthesis of 1-aryl-6-methyluracils
  作者：Harjit Singh、Palwinder Singh、Pawan Aggarwal、Subodh Kumar

  DOI：10.1039/p19930000731

  日期：——

  6-Methyl-1,3-oxazine-2,4(3H)-dione 1 reacts with 2 equiv. arylamines 3 at 150-160-degrees-C to give 1-aryl-6-methyluracils 5 or 1-aryl-3- (3-aryliminobutanoyl) ureas 4. The latter-as well as mixtures of 1 and 3 (2 equiv.) on refluxing, in isopentanol in some cases or in acetic acid in general-provide a facile synthesis of 5. The role of the stoichiometric excess of arylamines as against an equiv. of an alkylamine in similar reactions has been rationalized.
• Synthesis and transformations of 1-(4-hydroxyphenyl)dihydrouracils
  作者：R. S. Baltrushis、Z. -I. G. Beresnevichyus、V. Yu. Mitskyavichyus

  DOI：10.1007/bf00503202

  日期：1982.10