7-(2,5-二羟基-3,4,6-三甲基苯基)-7-苯基庚酸 | 148989-73-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 7-(2,5-二羟基-3,4,6-三甲基苯基)-7-苯基庚酸
• 英文名称: 7-(2,5-Dihydroxy-3,4,6-trimethylphenyl)-7-phenylheptanoic acid
• CAS: 148989-73-5
• 化学式: C₂₂H₂₈O₄
• 分子量: 356.462
• InChiKey: HYBOIQNYUNVBNF-UHFFFAOYSA-N

物化性质

• 沸点：
  586.5±50.0 °C(Predicted)
• 密度：
  1.153±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  7-(2,5-二羟基-3,4,6-三甲基苯基)-7-苯基庚酸 在 iron(III) chloride 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 生成 塞曲司特
  参考文献：
  名称：

  铟催化的环状1,3-二酮和醇类酮基酯的合成及其在Seratrodast的合成中的应用

  摘要：

  环状1,3-二酮和醇的酯化反应是在几种路易斯酸的存在下进行的。特别是，三氟甲磺酸铟（III），In（OTf）3，三氟甲磺酸铁（III），Fe（OTf）3，三氟甲磺酸铜（II），Cu（OTf）2和三氟甲磺酸银（I）AgOTf高。催化活性。这些反应通过逆向醇醛缩合反应进行碳-碳键裂解，即使在存在其他官能团的情况下，也具有很高的区域选择性。这种类型的反应也可以用于合成塞拉卓斯特期间的酮酯的制备，后者是一种抗哮喘和类二十烷酸拮抗剂。

  DOI：

  10.1002/asia.200900553
• 作为产物：
  描述：

  6-(氯甲酸基)己炔羧酸乙酯 在 sodium hydroxide 、 sodium tetrahydroborate 、 三氯化铝 、 三氟化硼乙醚 作用下， 以 四氢呋喃 、 甲醇 、 甲苯 为溶剂， 反应 7.5h， 生成 7-(2,5-二羟基-3,4,6-三甲基苯基)-7-苯基庚酸
  参考文献：
  名称：

  Quinones. 4. Novel eicosanoid antagonists: synthesis and pharmacological evaluation

  摘要：

  A new series of omega-phenyl-omega-quinonylalkanoic acids and related compounds was synthesized. The compounds were tested for their inhibitory effects on U-44069-induced contraction of the rabbit aorta. (+/- )-7-(3,5,6-Trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic acid (4d) (AA-2414) with pA2 value of 8.28 was one of the most potent compounds. Compound 4d inhibited U-46619-induced contraction of the guinea pig lung (pA2 = 8.29) and U-44069-induced aggregation of the guinea pig platelet (IC50 = 3.5 x 10(-7) M). Compound 4d displaced the binding of [3H]U-46619 to guinea pig platelets (IC50 = 7.4 x 10(-9) M). Compound 4d also showed very potent inhibitory effects with an MED of 0.3 mg/kg (po) on U-46619-, LTD4-, PAF-, or IgG1-induced bronchoconstriction in guinea pigs. The enantiomers of 4d were prepared. The R-(+) isomer 8a was active in both in vitro and in vivo tests, but the S-(-) isomer 8b was much less active. We concluded that the antiasthmatic effects of 4d were based mainly on the TXA2 receptor antagonistic action. In addition, compound 4d showed potent inhibitory effects on PGD2-, PGF2 alpha-, and 11-epi-PGF2 alpha-induced contraction of the guinea pig tracheal strips. The diverse inhibitory effects might be expressed in terms of eicosanoid-antagonistic activity.

  DOI：

  10.1021/jm00129a030

文献信息

• Process of preparing diphenylmethane derivatives
  申请人：TAKEDA CHEMICAL INDUSTRIES, LTD.

  公开号：EP0537954A1

  公开（公告）日：1993-04-21

  A diphenylmethane compound (III) can be produced in a good yield by allowing a phenol compound (I) to react with a stilbene compound (II) in the presence of methanesulfonic acid

  在甲磺酸存在下，让苯酚化合物（I）与二苯乙烯化合物（II）反应，可以生产出产率很高的二苯基甲烷化合物（III）。
• US5235091A
  申请人：——

  公开号：US5235091A

  公开（公告）日：1993-08-10
• Indium-Catalyzed Synthesis of Keto Esters from Cyclic 1,3-Diketones and Alcohols and Application to the Synthesis of Seratrodast
  作者：Yoichiro Kuninobu、Atsushi Kawata、Taihei Noborio、Syun-ichi Yamamoto、Takashi Matsuki、Kazumi Takata、Kazuhiko Takai

  DOI：10.1002/asia.200900553

  日期：2010.4.1

  iron(III) triflate, Fe(OTf)3, copper(II) triflate, Cu(OTf)2, and silver(I) triflate, AgOTf, show high catalytic activities. These reactions proceed through the carbon–carbon bond cleavage by a retro‐aldol reaction and were found to be highly regioselective even in the presence of other functional groups. This type of reaction can also be applied to the preparation of the keto esters during the synthesis

  环状1,3-二酮和醇的酯化反应是在几种路易斯酸的存在下进行的。特别是，三氟甲磺酸铟（III），In（OTf）3，三氟甲磺酸铁（III），Fe（OTf）3，三氟甲磺酸铜（II），Cu（OTf）2和三氟甲磺酸银（I）AgOTf高。催化活性。这些反应通过逆向醇醛缩合反应进行碳-碳键裂解，即使在存在其他官能团的情况下，也具有很高的区域选择性。这种类型的反应也可以用于合成塞拉卓斯特期间的酮酯的制备，后者是一种抗哮喘和类二十烷酸拮抗剂。
• Quinones. 4. Novel eicosanoid antagonists: synthesis and pharmacological evaluation
  作者：Mitsuru Shiraishi、Kaneyoshi Kato、Shinji Terao、Yasuko Ashida、Zenichi Terashita、Go Kito

  DOI：10.1021/jm00129a030

  日期：1989.9

  A new series of omega-phenyl-omega-quinonylalkanoic acids and related compounds was synthesized. The compounds were tested for their inhibitory effects on U-44069-induced contraction of the rabbit aorta. (+/- )-7-(3,5,6-Trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic acid (4d) (AA-2414) with pA2 value of 8.28 was one of the most potent compounds. Compound 4d inhibited U-46619-induced contraction of the guinea pig lung (pA2 = 8.29) and U-44069-induced aggregation of the guinea pig platelet (IC50 = 3.5 x 10(-7) M). Compound 4d displaced the binding of [3H]U-46619 to guinea pig platelets (IC50 = 7.4 x 10(-9) M). Compound 4d also showed very potent inhibitory effects with an MED of 0.3 mg/kg (po) on U-46619-, LTD4-, PAF-, or IgG1-induced bronchoconstriction in guinea pigs. The enantiomers of 4d were prepared. The R-(+) isomer 8a was active in both in vitro and in vivo tests, but the S-(-) isomer 8b was much less active. We concluded that the antiasthmatic effects of 4d were based mainly on the TXA2 receptor antagonistic action. In addition, compound 4d showed potent inhibitory effects on PGD2-, PGF2 alpha-, and 11-epi-PGF2 alpha-induced contraction of the guinea pig tracheal strips. The diverse inhibitory effects might be expressed in terms of eicosanoid-antagonistic activity.